World-wide survey of an Accord insertion and its association with DDT resistance in Drosophila melanogaster

Molecular Ecology
F CataniaC Schlotterer

Abstract

Previous work showed that insecticide resistance in Drosophila melanogaster is correlated with the insertion of an Accord-like element into the 5' region of the cytochrome P450 gene, Cyp6g1. Here, we study the distribution of the Accord-like element in 673 recently collected D. melanogaster lines from 34 world-wide populations. We also examine the extent of microsatellite variability along a 180-kilobase (kb) genomic region of chromosome II encompassing the resistance gene. We confirm a 100% correlation of the Accord insertion with insecticide resistance and a significant reduction in variability extending at least 20 kb downstream of the Cyp6g1 gene. The frequency of the Accord insertion differs significantly between East African (32-55%) and nonAfrican (85-100%) populations. This pattern is consistent with a selective sweep driving the Accord insertion close to fixation in nonAfrican populations as a result of the insecticide resistance phenotype it confers. This study confirms that hitchhiking mapping can be used to identify beneficial mutations in natural populations.

References

Apr 1, 1988·Trends in Genetics : TIG·J R David, P Capy
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Feb 1, 1974·Genetical Research·J M Smith, J Haigh
Dec 1, 1995·Science·M F TaylorM E Kreitman
Jul 1, 1997·Emerging Infectious Diseases·D R RobertsL J Legters
Aug 13, 1998·Seminars in Thrombosis and Hemostasis·A IchinoseT Saito
Dec 29, 1998·Molecular Biology and Evolution·M D SchugC F Aquadro
Feb 17, 1999·Annual Review of Entomology·R Feyereisen
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·M H KohnR K Wayne
Sep 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·P S SchmidtW F Eanes
Jan 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yoav GiladKarl Skorecki
Jul 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Y VigourouxJ Doebley
Sep 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Bettina HarrChristian Schlötterer
Sep 28, 2002·Science·P J DabornR H ffrench-Constant
Dec 21, 2002·Trends in Genetics : TIG·Christian Schlötterer
Jun 5, 2003·Molecular Biology and Evolution·Maximilian KauerChristian Schlötterer
Jun 27, 2003·Insect Biochemistry and Molecular Biology·G Le GoffR H ffrench-Constant
Jan 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Todd A Schlenke, David J Begun

❮ Previous
Next ❯

Citations

Jan 18, 2008·Molecular Biology and Evolution·J Michael MacphersonDmitri A Petrov
Nov 22, 2011·Molecular Biology and Evolution·Sarah S Saminadin-PeterJohn Parsch
Jan 23, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Nina Wedell
Nov 13, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Amanda Glaser-SchmittJohn Parsch
Aug 24, 2006·Annual Review of Entomology·Xianchun LiMay R Berenbaum
Feb 1, 2011·BMC Genomics·Lena MüllerJohn Parsch
Dec 19, 2006·PLoS Genetics·Pleuni S Pennings, Joachim Hermisson
Feb 18, 2005·Genetics·Joachim Hermisson, Pleuni S Pennings
Sep 22, 2012·Genetics·Yuh Chwen G Lee, Charles H Langley
Mar 12, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Lee Butler, Karen Pilkington
Aug 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael R BogwitzPhillip J Daborn
Jun 29, 2010·Pesticide Biochemistry and Physiology·Maeva GiraudoRené Feyereisen
Jun 27, 2009·Gene·Josefa González, Dmitri A Petrov
Jul 22, 2005·Journal of Evolutionary Biology·C Lexer, M F Fay
Jun 12, 2010·Pest Management Science·Alexandra Brun-BaraleRené Feyereisen
Jun 29, 2010·Pest Management Science·Robert T JonesJean M H van den Elsen
Apr 22, 2011·Journal of Evolutionary Biology·D T SmithN Wedell
Aug 8, 2006·International Journal for Parasitology·John Stuart Gilleard
Nov 29, 2005·Journal of Insect Physiology·Julian A T Dow, Shireen A Davies
Jun 3, 2015·BMC Biology·Wayne G RostantDavid J Hosken

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.