World Workshop on Oral Medicine VII: Burning mouth syndrome: A systematic review of disease definitions and diagnostic criteria utilized in randomized clinical trials

Oral Diseases
Anura AriyawardanaCraig S Miller

Abstract

To conduct a systematic review analyzing disease definitions and diagnostic criteria used in randomized controlled trials (RCTs) involving burning mouth syndrome (BMS). A systematic search conducted in PubMed, Web of Science, PsycINFO, Cochrane Database/Cochrane Central, and Google Scholar that included RCTs on BMS published between 1994 and 2017 was performed. Considerable variability in BMS disease definitions and diagnostic criteria used created substantial heterogeneity in the selection of participants and weakened the rigor of the 36 RCTs identified. The analyzed RCTs routinely under-reported the methods used to rule in or out study participants and the number of individuals excluded from BMS RCTs. Our findings indicate that a large proportion of participants enrolled in these studies may have had an underlying condition that could have explained their BMS symptoms. Thus, outcomes of therapeutic interventions from these BMS RCTs should be interpreted with caution due to heterogeneous disease definitions and diagnostic criteria. In order to improve the quality of clinical trials, future research should focus on establishing consensus for a single definition of BMS that includes specific inclusion and exclusion criteria that...Continue Reading

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Citations

Aug 30, 2019·Oral Diseases·Takayuki SugaAkira Toyofuku
Aug 30, 2019·Oral Diseases·Anura AriyawardanaCraig S Miller
Apr 16, 2020·Oral Diseases·M de PedroG Hernández
Apr 2, 2020·Journal of Clinical Medicine·Pia Lopez-JornetAsta Tvarijonaviciute
Nov 5, 2019·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Jacob E FreilichAlessandro Villa
Mar 7, 2021·Nutrients·Pia López-JornetAsta Tvarijonaviciute
May 11, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hasan HodajJean-Pascal Lefaucheur
Oct 17, 2020·Clinical Oral Investigations·Anne WolowskiH Hörning

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