Worldwide distribution of the MYH9 kidney disease susceptibility alleles and haplotypes: evidence of historical selection in Africa.

PloS One
Taras K OleksykCheryl A Winkler

Abstract

MYH9 was recently identified as renal susceptibility gene (OR 3-8, p < 10(-8)) for major forms of kidney disease disproportionately affecting individuals of African descent. The risk haplotype (E-1) occurs at much higher frequencies in African Americans (> or = 60%) than in European Americans (< 4%), revealing a genetic basis for a major health disparity. The population distributions of MYH9 risk alleles and the E-1 risk haplotype and the demographic and selective forces acting on the MYH9 region are not well explored. We reconstructed MYH9 haplotypes from 4 tagging single nucleotide polymorphisms (SNPs) spanning introns 12-23 using available data from HapMap Phase II, and by genotyping 938 DNAs from the Human Genome Diversity Panel (HGDP). The E-1 risk haplotype followed a cline, being most frequent within sub-Saharan African populations (range 50-80%), less frequent in populations from the Middle East (9-27%) and Europe (0-9%), and rare or absent in Asia, the Americas, and Oceania. The fixation indexes (F(ST)) for pairwise comparisons between the risk haplotypes for continental populations were calculated for MYH9 haplotypes; F(ST) ranged from 0.27-0.40 for Africa compared to other continental populations, possibly due to sel...Continue Reading

References

May 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B I FreedmanB J Spray
Oct 1, 1995·Genetics·H J BandeltM B Richards
Jan 9, 2001·Trends in Ecology & Evolution·D Posada, K A Crandall
Dec 6, 2002·Genome Research·Joshua M AkeyMark D Shriver
Dec 21, 2002·Science·Noah A RosenbergMarcus W Feldman
Mar 7, 2003·Nature·Luc VanhammeEtienne Pays
Jul 17, 2003·Kidney International. Supplement·Jeffrey B Kopp, Cheryl Winkler
Oct 21, 2005·Nature·Carlos D BustamanteAndrew G Clark
Oct 28, 2005·Genome Research·Bruce S WeirWilliam G Hill
Oct 29, 2005·Nature·UNKNOWN International HapMap Consortium
Dec 3, 2005·The Journal of Infectious Diseases·Sadeep ShresthaMichael W Smith
Dec 27, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Doron M BeharKarl Skorecki
Dec 31, 2005·American Journal of Human Genetics·Kirk E LohmuellerJohn M Braverman
Feb 24, 2006·PLoS Biology·Benjamin F VoightJonathan K Pritchard
Jun 17, 2006·Science·P C SabetiE S Lander
Aug 23, 2006·Nature Reviews. Genetics·Laurent Excoffier, Gerald Heckel
Oct 24, 2006·Nature Genetics·Donald F ConradJonathan K Pritchard
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Oct 19, 2007·Nature·UNKNOWN International HapMap ConsortiumJohn Stewart
Nov 8, 2007·JAMA : the Journal of the American Medical Association·Josef CoreshAndrew S Levey
Feb 22, 2008·Nature·Mattias JakobssonAndrew B Singleton
Apr 18, 2008·Briefings in Bioinformatics·Sudhir KumarKoichiro Tamura
Sep 17, 2008·Nature Genetics·W H Linda KaoUNKNOWN Family Investigation of Nephropathy and Diabetes Research Group
Sep 17, 2008·Nature Genetics·Jeffrey B KoppCheryl A Winkler
Mar 25, 2009·Genome Research·Joseph K PickrellJonathan K Pritchard
Jun 30, 2009·Current Opinion in Immunology·Etienne Pays, Benoit Vanhollebeke
Jul 2, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Barry I FreedmanDonald W Bowden
Sep 12, 2009·Molecular Biology and Evolution·Daniel GarriganJohn Wakeley
Sep 25, 2009·Nature Reviews. Nephrology·June Fabian, Saraladevi Naicker
Sep 29, 2009·Human Molecular Genetics·Fuli YuDavid Reich
Dec 17, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Taras K OleksykStephen J O'Brien
Dec 23, 2009·Genome Biology·Fouad ZakhariaHua Tang
Feb 25, 2010·Current Biology : CB·Jonathan K PritchardGraham Coop
Nov 1, 1984·Evolution; International Journal of Organic Evolution·B S Weir, C Clark Cockerham

❮ Previous
Next ❯

Citations

Aug 15, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Robert KalyesubulaKasonde Bowa
Sep 30, 2010·Human Molecular Genetics·Brenna M HennCarlos D Bustamante
Mar 25, 2011·Human Molecular Genetics·Conall M O'SeaghdhaW H Linda Kao
Sep 6, 2011·Human Molecular Genetics·Jingyuan FuCisca Wijmenga
Oct 15, 2011·Journal of the American Society of Nephrology : JASN·Jeffrey B KoppCheryl A Winkler
Nov 10, 2011·Current Hypertension Reports·Barry I Freedman, Mariana Murea
Jan 10, 2013·PloS One·Duncan B JohnstoneLawrence B Holzman
May 4, 2011·Nature Reviews. Nephrology·Saharon RossetKarl Skorecki
Dec 7, 2011·Nature Reviews. Nephrology·Conall M O'Seaghdha, Caroline S Fox
Sep 8, 2012·International Urology and Nephrology·Bamidele O TayoRichard S Cooper
Oct 15, 2013·Seminars in Nephrology·Holly KramerSylvia E Rosas
Aug 30, 2014·Advances in Chronic Kidney Disease·Sophie LimouCheryl A Winkler
Aug 7, 2010·Journal of the American Society of Nephrology : JASN·Barry I FreedmanMartin R Pollak
Feb 11, 2014·Journal of the American Society of Nephrology : JASN·Wen Y DingMoin A Saleem
May 3, 2019·Clinical Transplantation·Sapna ShahMadhav C Menon
Sep 20, 2019·International Journal of Nephrology·Cyril CyrusAmein K Al Ali
Jul 10, 2019·Genetics·Rohan S MehtaNoah A Rosenberg
Oct 23, 2018·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Barry I FreedmanJeffrey B Kopp
Sep 1, 2019·Genetics·Rohan S MehtaNoah A Rosenberg

❮ Previous
Next ❯

Software Mentioned

Hapmap
MEGA
Happlotter browser
SAS
SAS Genetics
Network
HGDP selection browser
HGDP browser
Haplotter
Arlequin

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.