Worldwide frequency of a common genetic variant of luteinizing hormone: an international collaborative research. International Collaborative Research Group

Fertility and Sterility
C H NilssonIlpo T Huhtaniemi

Abstract

To determine the worldwide frequency of a common immunological LH variant because of two point mutations in the LH beta-subunit gene (Trp8Arg and Ile15Thr). Cross-sectional study on LH status (variant and wild-type) in serum (or DNA) samples from Finland (Finns and Lapps), Estonia, Poland, Sweden, The Netherlands, United Kingdom, Italy, South Africa (blacks), Thailand, China, Japan, and the United States (Hispanics and blacks). Academic research environment. Ambulatory adult men and women (n = 2,936) with minor illnesses and no known endocrinological disorders. A single blood sample was collected from each subject. The LH status was determined by two immunofluorometric assays using monoclonal antibodies. One (assay 1) only recognizes the wild-type LH, the other (assay 2) recognizes equally variant and wild-type LH. The ratio of assay 1 to assay 2 indicates the LH status: wild-type, > 0.9; heterozygote, 0.2 to 0.9; and homozygote, < 0.15. One population (Lapps) was studied by DNA analysis using polymerase chain reaction and allele-specific oligonucleotide hybridization. The carrier frequency of the variant LH beta allele varied from 7.1% in U.S. Hispanics to 41.9% in Lapps of northern Finland. The variant LH beta allele tended t...Continue Reading

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Citations

Sep 14, 2011·Reviews in Endocrine & Metabolic Disorders·Livio CasariniManuela Simoni
Jul 20, 1999·Molecular and Cellular Endocrinology·I HuhtaniemiK Pettersson
Jul 27, 1999·The Journal of Steroid Biochemistry and Molecular Biology·I T Huhtaniemi, K S Pettersson
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