Apr 7, 2020

Adhatoda Vasica ameliorates cellular hypoxia dependent mitochondrial dysfunction in acute and severe asthmatic mice.

BioRxiv : the Preprint Server for Biology
A. P. GhewareBhavana Prasher

Abstract

Severe asthma is chronic airway disease, exhibit poor response to conventional asthma therapies. Growing evidence suggests that elevated hypoxia increases the severity of asthmatic inflammation among patient and model systems. In this study, we elucidate the therapeutic effect and mechanistic basis of Adhatoda Vasica (AV) aqueous extract on acute allergic as well as severe asthma subtypes, at physiological, histopathological and molecular levels using mouse models. We observed, oral administration of AV extract not only attenuates the increased airway resistance and inflammation in acute allergic asthmatic mice but also alleviates the molecular signatures of steroid (dexamethasone) resistance like IL-17A, KC and HIF-1 (hypoxia inducible factor-1alpha) in severe asthmatic mice. The reversal of pathophysiological features after AV treatment is associated with inhibition of elevated HIF-1 levels by restoring the expression of its negative regulator-PHD2 (prolyl hydroxylase domain-2). This was further confirmed in acute and severe asthma model developed by augmented hypoxic response. Further, AV treatment reverses cellular hypoxia- induced mitochondrial dysfunction in human bronchial epithelial cells - evident from bioenergetic pro...Continue Reading

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Mentioned in this Paper

Genome-Wide Association Study
Study
Tumor Necrosis Factor-alpha
Genome
Genes
Pathogenic Organism
Helicobacter pylori
Transcription, Genetic
Genomic Stability
Genomics

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