Worm chips: microtools for C. elegans biology

Lab on a Chip
Nikos Chronis

Abstract

The study of small-size animal models, such as the roundworm C. elegans, has provided great insight into several in vivo biological processes, extending from cell apoptosis to neural network computing. The physical manipulation of this micron-sized worm has always been a challenging task. Here, we discuss the applications, capabilities and future directions of a new family of worm manipulation tools, the 'worm chips'. Worm chips are microfabricated devices capable of precisely manipulating single worms or a population of worms and their environment. Worm chips pose a paradigm shift in current methodologies as they are capable of handling live worms in an automated fashion, opening up a new direction in in vivo small-size organism studies.

References

Jan 1, 1993·Annual Review of Neuroscience·C I Bargmann
Apr 22, 2004·Lab on a Chip·Elisabeth Verpoorte
Dec 4, 2004·The EMBO Journal·Massimo A HilliardWilliam R Schafer
Dec 17, 2004·Nature·Mehmet Fatih YanikAdela Ben-Yakar
Aug 3, 2005·Analytical and Bioanalytical Chemistry·Petra S Dittrich, Andreas Manz
Jul 28, 2006·Nature·George M Whitesides
Feb 3, 2007·Lab on a Chip·Jianhua Qin, Aaron R Wheeler
Aug 24, 2007·Lab on a Chip·Anette FunfakJohann Michael Köhler
Aug 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Christopher B RohdeMehmet Fatih Yanik
Oct 26, 2007·Lab on a Chip·S Elizabeth HulmeGeorge M Whitesides
Oct 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sung-Jin ParkBeth L Pruitt
Nov 2, 2007·Nature·Sreekanth H ChalasaniCornelia I Bargmann
Mar 14, 2008·Journal of Neurophysiology·S R LockeryB L Pruitt
Apr 15, 2008·Nature Methods·Samuel X GuoAdela Ben-Yakar
Jun 24, 2008·Nature Methods·Kwanghun ChungHang Lu
Jun 27, 2008·Journal of Neuroscience Methods·Peter B AllenDaniel T Chiu
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Xiquan CuiChanghuei Yang
Aug 7, 2008·Journal of the Royal Society, Interface·Tzu-Chiao Chao, Alexandra Ros
Sep 27, 2008·Lab on a Chip·Weiwei ShiBingcheng Lin
Feb 12, 2009·Lab on a Chip·Trushal Vijaykumar ChokshiNikos Chronis
May 7, 2009·Lab on a Chip·Joseph C DollBeth L Pruitt
Mar 16, 1998·Angewandte Chemie·Younan Xia, George M Whitesides

❮ Previous
Next ❯

Citations

Feb 22, 2013·Chemical Reviews·Venkataragavalu Sivagnanam, Martin A M Gijs
Oct 5, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Suzanne TharinJeffrey D Macklis
Mar 25, 2014·Lab on a Chip·Jiseok LimJean-Christophe Baret
Mar 31, 2012·Lab on a Chip·Pouya RezaiBhagwati P Gupta
Feb 10, 2016·Molecular Neurodegeneration·Matteo CornagliaMartin A M Gijs
Aug 27, 2010·Current Opinion in Neurobiology·Anne M Taylor, Noo Li Jeon
Sep 18, 2014·Scientific Reports·Joseph P DexterEva-Maria S Collins
Dec 4, 2015·Biomicrofluidics·Lukas C GerberIngmar H Riedel-Kruse
Mar 7, 2015·Biomedical Microdevices·Pengfei SongXinyu Liu
Nov 3, 2010·Chemistry & Biology·Saurabh VyawahareChristoph A Merten
May 11, 2016·Lab on a Chip·Andy TayDino Di Carlo
Aug 5, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muniesh Muthaiyan Shanmugam, Tuhin Subhra Santra
Jun 13, 2018·Annual Review of Analytical Chemistry·Farhan Kamili, Hang Lu
Jul 11, 2018·Lab on a Chip·Krishna N BadhiwalaJacob T Robinson
Sep 4, 2020·Microsystems & Nanoengineering·Lisa F HorowitzAlbert Folch
Jun 30, 2019·Integrative Biology : Quantitative Biosciences From Nano to Macro·Khaled YoussefPouya Rezai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.