WormBase: a comprehensive resource for nematode research

Nucleic Acids Research
Todd W HarrisPaul W Sternberg

Abstract

WormBase (http://www.wormbase.org) is a central data repository for nematode biology. Initially created as a service to the Caenorhabditis elegans research field, WormBase has evolved into a powerful research tool in its own right. In the past 2 years, we expanded WormBase to include the complete genomic sequence, gene predictions and orthology assignments from a range of related nematodes. This comparative data enrich the C. elegans data with improved gene predictions and a better understanding of gene function. In turn, they bring the wealth of experimental knowledge of C. elegans to other systems of medical and agricultural importance. Here, we describe new species and data types now available at WormBase. In addition, we detail enhancements to our curatorial pipeline and website infrastructure to accommodate new genomes and an extensive user base.

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Methods Mentioned

BETA
RNA-Seq
Illumina sequencing

Software Mentioned

BLAST
Browse
TreeFam
Reactome
Textpresso
InParanoid
BioCyc
SPELL ( Serial Patterns of Expression Levels Locator )
Perl
Ensembl Compara

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