Worse outcome after stroke in patients with obstructive sleep apnea: an observational cohort study

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Meghna P MansukhaniLatha G Stead

Abstract

To evaluate the risk and presence of obstructive sleep apnea (OSA) in patients presenting with acute ischemic stroke, and examine the correlation of OSA with age, sex, ischemic stroke subtype, disability, and death, a prospective cohort study was conducted in all consecutive patients presenting with acute ischemic stroke between June 2007 and March 2008. Exclusion criteria were age < 18 years, refusal of consent for the study, and incomplete questionnaire. The Berlin Sleep Questionnaire was used to identify patients at high risk for OSA. A total of 174 patients with acute ischemic stroke were included; 130 (74.7%) had a modified Rankin Scale (mRS) score ≥ 3 at dismissal, and 11 patients (6.3%) died within 1 month. The Berlin Sleep Questionnaire identified 105 patients (60.4%) at high risk for OSA, along with 7 patients (4%) with a previous diagnosis of OSA. Those with a previous diagnosis of OSA were more likely to die within the first month after stroke (relative risk, 5.3; 95% confidence interval, 1.4-20.1) compared with those without OSA. Patients at high risk for OSA did not demonstrate increased mortality at 30 days (P = 1.0). In multivariate analysis, after adjusting for age and National Institutes of Health Stroke Scale ...Continue Reading

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Citations

Apr 5, 2014·Continuum : Lifelong Learning in Neurology·Shyam Prabhakaran, Ji Y Chong
Jun 10, 2014·BMC Research Notes·Jittima SaengsuwanKittisak Sawanyawisuth
Dec 23, 2014·The American Journal of Cardiology·Dmitry M YaranovMark K Warshofsky
Aug 1, 2016·Sleep & Breathing = Schlaf & Atmung·Laura B PonsaingPoul Jennum
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Feb 9, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yeying WangYongxia Li
Sep 12, 2015·Annals of Rehabilitation Medicine·Jinil KimSoo A Kim
Jul 19, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Meghna P MansukhaniVirend K Somers
Dec 29, 2018·AJNR. American Journal of Neuroradiology·C D StreibT G Jovin
Mar 15, 2018·Frontiers in Surgery·David StevensAndrew Vakulin
Sep 2, 2016·Annals of the American Thoracic Society·Andrew M NamenEdward F Haponik
Jan 16, 2020·Sleep & Breathing = Schlaf & Atmung·Akseli LeinoKatja Myllymaa
Apr 22, 2021·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Gülgün Çetintaş AfşarCüneyt Saltürk
Apr 6, 2021·Aging and Disease·Hongxia CaiGuo-Yuan Yang

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