Abstract
To examine whether increasing fasting plasma glucose (FPG) levels were associated with worsening left ventricular (LV) diastolic function, independently of LV mass index (LVMI) in elderly, otherwise healthy subjects. We tested cross-sectional associations between echocardiographically determined averaged E/é ratio/diastolic function, LVMI, cardiovascular risk factors, and FPG categorized as normal (NFG), impaired (IFG), and new-onset diabetes mellitus (DM), in 483 men and 208 women aged 56-79 years without overt cardiovascular disease, who received no cardiovascular, anti-diabetic, or lipid-lowering drugs and had a preserved LV ejection fraction >50%. Median E/é was significantly higher among subjects with diabetes than those without (8 vs. 7; p = 0.03), as was the prevalence of grade 2 or 3 diastolic dysfunction (25% vs. 16%; p = 0.02). E/é and diastolic function were significantly associated with LVMI (p ≤ 0.002), but not FPG category, on multivariable analysis. However, interaction analyses revealed that increasing LVMI was primarily associated with worsening diastolic function (higher E/é) in subjects with FPG > 6 mmol/L (β=0.005 for IFG and DM vs. 0.001 for NFG; p = 0.02), whereas increasing systolic blood pressure was pri...Continue Reading
References
Nov 18, 2000·Journal of the American College of Cardiology·M S FirstenbergJ D Thomas
Sep 5, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·N UnwinK G M M Alberti
Jan 9, 2003·JAMA : the Journal of the American Medical Association·Margaret M RedfieldRichard J Rodeheffer
Jun 14, 2003·The American Journal of Cardiology·Mehdi H ShishehborMario J Garcia
Mar 31, 2004·The American Journal of Cardiology·John K BoyerJulio E Pérez
Jul 9, 2005·Progress in Cardiovascular Diseases·Michael R ZileDavid D Bonnema
Jan 13, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·P Di BonitoG Sibilio
Feb 21, 2006·Heart·W P AbhayaratnaN G Becker
Dec 21, 2006·Circulation·Victor J DzauWilliam Stevenson
Dec 21, 2006·Circulation·Victor J DzauWilliam Stevenson
Nov 13, 2008·The New England Journal of Medicine·Barry M MassieUNKNOWN I-PRESERVE Investigators
Feb 4, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sherif F NaguehArturo Evangelista
May 12, 2009·The American Journal of Cardiology·Aaron M FromHorng H Chen
Mar 10, 2010·American Heart Journal·Margret LeosdottirVilmundur Gudnason
Mar 10, 2010·European Journal of Heart Failure·Cesare RussoMarco R Di Tullio
Apr 14, 2010·Diabetologia·R StahrenbergR Wachter
Nov 9, 2010·Vascular Medicine·Michael F O'RourkeVictor Dzau
Jun 15, 2011·Circulation·Carolyn S P LamRamachandran S Vasan
Aug 30, 2011·Diabetes Care·Marina De MarcoRichard B Devereux
May 9, 2012·European Journal of Heart Failure·Gian Francesco MuredduUNKNOWN PREDICTOR Study Group
Dec 3, 2013·Journal of the American College of Cardiology·Siu-Hin WanHorng H Chen
Jan 28, 2014·Pharmacology & Therapeutics·Karina HuynhRebecca H Ritchie
Jul 10, 2014·The New England Journal of Medicine·Marc A PfefferSonja M McKinlay
Citations
Dec 15, 2015·BMC Cardiovascular Disorders·Mette Lundgren NielsenMichael Hecht Olsen
May 27, 2015·International Journal of Cardiology·Manan PareekMichael Hecht Olsen
May 26, 2015·International Journal of Cardiology·Tomoyuki Kawada
Mar 27, 2018·Scandinavian Journal of Public Health·L VähämurtoK Pahkala
Jun 24, 2017·European Journal of Preventive Cardiology·Manan PareekMichael H Olsen
Jul 25, 2018·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Selma BouthoornFrans H Rutten
Aug 22, 2018·Blood Pressure·Ewa ŚwierblewskaKrzysztof Narkiewicz
Mar 16, 2019·Journal of the American Heart Association·Congyi ZhengZengwu Wang