Worsening of ischemic damage in hearts from rats with selective growth hormone deficiency

European Journal of Pharmacology
V De Gennaro ColonnaF Berti

Abstract

The effects of growth hormone (GH) deficiency on cardiac function were studied in young male rats administered an anti-GH-releasing hormone (GHRH) serum from postnatal day 20 to 40. Dependence of heart abnormalities on GH deficiency was ascertained by giving a group of anti-GHRH serum-treated rats GH replacement therapy. Heart preparations from anti-GHRH serum-treated rats, undergoing low-flow ischemia, showed a progressive increase in left ventricular end-diastolic pressure with poor recovery of mechanical activity and increased coronary perfusion pressure upon reperfusion. Hearts from anti-GHRH serum + GH-treated rats, undergoing global reduction to the flow, showed only a minimal increase of left ventricular end-diastolic pressure and, upon reperfusion, cardiac mechanical activity recovered almost completely. Similar findings were also observed in heart preparations from control (normal rabbit serum-treated) rats. Infusion of acetylcholine (10(-6) M) into heart preparations in the preischemic period increased coronary perfusion pressure values more markedly in hearts from normal rabbit serum- and anti-GHRH serum + GH-treated rats than in those from anti-GHRH serum-treated rats. These results indicate that selective GH defici...Continue Reading

References

Jan 1, 1989·Acta Paediatrica Scandinavica. Supplement·S ShakutsuiK Chihara
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R BenoitR Guillemin
Sep 1, 1984·Endocrinology·W B WehrenbergB J Phillips
Dec 1, 1993·The Journal of Clinical Endocrinology and Metabolism·B MerolaG Lombardi

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Citations

Dec 13, 2001·European Journal of Pharmacology·J T MacAndrewS C Black
Oct 24, 2002·Neurobiology of Aging·Eugenio E MullerSilvano G Cella
Feb 9, 2005·Kidney International·Zhilan ZhengRalph Rabkin
Sep 25, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·K E HatzistergosV Malamou-Mitsi
Sep 16, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·F BertiG Rossoni
Jul 11, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·G RossoniF Berti

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