Abstract
The effects of growth hormone (GH) deficiency on cardiac function were studied in young male rats administered an anti-GH-releasing hormone (GHRH) serum from postnatal day 20 to 40. Dependence of heart abnormalities on GH deficiency was ascertained by giving a group of anti-GHRH serum-treated rats GH replacement therapy. Heart preparations from anti-GHRH serum-treated rats, undergoing low-flow ischemia, showed a progressive increase in left ventricular end-diastolic pressure with poor recovery of mechanical activity and increased coronary perfusion pressure upon reperfusion. Hearts from anti-GHRH serum + GH-treated rats, undergoing global reduction to the flow, showed only a minimal increase of left ventricular end-diastolic pressure and, upon reperfusion, cardiac mechanical activity recovered almost completely. Similar findings were also observed in heart preparations from control (normal rabbit serum-treated) rats. Infusion of acetylcholine (10(-6) M) into heart preparations in the preischemic period increased coronary perfusion pressure values more markedly in hearts from normal rabbit serum- and anti-GHRH serum + GH-treated rats than in those from anti-GHRH serum-treated rats. These results indicate that selective GH defici...Continue Reading
References
May 1, 1976·Acta Endocrinologica·J LindholmO Korsgaard
Oct 1, 1992·Neuroendocrinology·W B WehrenbergR C Gaillard
Jan 1, 1992·British Heart Journal·M ShahiR A Foale
Aug 4, 1990·Lancet·T Rosén, B A Bengtsson
Oct 1, 1990·Endocrinology·S G CellaW B Wehrenberg
Oct 1, 1988·Journal of Cardiovascular Pharmacology·F BertiG Galli
May 1, 1989·Molecular and Cellular Endocrinology·G L EngelmannJ Ilan
Jun 1, 1989·Endocrinology·Y ArsenijevicM L Aubert
Jan 1, 1989·Acta Paediatrica Scandinavica. Supplement·S ShakutsuiK Chihara
Sep 1, 1989·The Journal of Endocrinology·K E BornfeldtG Norstedt
Feb 1, 1986·Endocrinology·W B Wehrenberg
Mar 1, 1988·Molecular Endocrinology·P ChomczynskiL A Frohman
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R BenoitR Guillemin
Jun 9, 1983·Nature·J SpiessW Vale
Sep 1, 1984·Endocrinology·W B WehrenbergB J Phillips
Sep 1, 1994·Pediatric Research·S G CellaE E Müller
Jan 1, 1994·The Journal of Endocrinology·S G CellaE E Müller
Dec 1, 1993·The Journal of Clinical Endocrinology and Metabolism·B MerolaG Lombardi
Citations
Dec 13, 2001·European Journal of Pharmacology·J T MacAndrewS C Black
Nov 22, 1997·European Journal of Pharmacology·V De Gennaro ColonnaF Berti
Oct 24, 2002·Neurobiology of Aging·Eugenio E MullerSilvano G Cella
Aug 13, 1998·Journal of Cardiovascular Pharmacology·G RossoniF Berti
Sep 2, 1999·Journal of Cardiovascular Pharmacology·G RossoniF Berti
Feb 9, 2005·Kidney International·Zhilan ZhengRalph Rabkin
Sep 25, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·K E HatzistergosV Malamou-Mitsi
Sep 16, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·F BertiG Rossoni
Jul 11, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·G RossoniF Berti
Aug 28, 1999·Endocrinology·V LocatelliF Berti
May 26, 1999·Journal of Endocrinological Investigation·G BisiE Ghigo
Feb 26, 2021·Stem Cell Research & Therapy·Sevil Korkmaz-IcözGábor Szabó
Jun 3, 2021·Cells·Sevil Korkmaz-IcözGábor Szabó