Worsening of obsessive-compulsive symptoms under methadone tapering

Progress in Neuro-psychopharmacology & Biological Psychiatry
Yasser KhazaalDaniele Fabio Zullino

Abstract

There is data supporting the hypothesis that the endogenous opioid system may play a role in the pathophysiology of Obsessive Compulsive Disorder (OCD). The authors report a case of worsening of OCD during methadone tapering, which seems to confirm the role of the opioid system in the pathophysiology of OCD. The possible involvement of the cortico-limbic-basal-ganglia-thalamic circuit in the observed phenomenon is discussed.

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Citations

Oct 30, 2008·Journal of Addictive Diseases·Peter L Tenore
Jan 18, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Martijn FigeeDamiaan Denys
Sep 26, 2014·Expert Opinion on Pharmacotherapy·Stefano Pallanti, Giacomo Grassi
Jun 10, 2010·Journal of Psychopharmacology·A ColasantiD J Nutt
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Jan 7, 2015·Current Protocols in Neuroscience·Anushka B P FernandoTrevor W Robbins
Dec 3, 2016·Canadian Journal of Physiology and Pharmacology·Arezoo Hammami-Abrand Abadi, Hossein Miladi-Gorji

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