Worsening renal failure in patients with acute heart failure: the importance of cardiac biomarkers

ESC Heart Failure
Akihiro ShirakabeWataru Shimizu

Abstract

The importance of true worsening renal failure (WRF), which is associated with a poor prognosis, had been suggested in patients with acute heart failure (AHF). The aim of the present study was to establish the biomarker strategy for the prediction of true WRF in AHF. Two hundred eighty-one patients with AHF were analysed. Their biomarkers were measured within 30 min of admission. Patients were assigned to the non-WRF (n = 168), pseudo-WRF (n = 56), or true-WRF (n = 57) groups using the criteria of both acute kidney injury on admission and increasing serum creatinine value during the first 7 days. A Kaplan-Meier curve showed that the survival and heart failure event rate of the true-WRF group within 1000 days was significantly lower than that of the non-WRF and pseudo-WRF groups (P ≤ 0.001). The multivariate Cox regression model also indicated that true WRF was an independent predictor of 1000 day mortality and heart failure events [hazard ratio: 4.315, 95% confidence interval (CI): 2.466-7.550, P ≤ 0.001, and hazard ratio: 2.834, 95% CI: 1.893-4.243, P ≤ 0.001, respectively]. The serum heart-type fatty acid-binding protein (s-HFABP) levels were significantly higher in the true-WRF group than in the non-WRF and pseudo-WRF groups...Continue Reading

References

Jun 9, 1993·Molecular and Cellular Biochemistry·J H Veerkamp, H T van Moerkerk
Jan 13, 2004·Journal of the American College of Cardiology·Daniel E FormanHarlan M Krumholz
Sep 18, 2004·The American Journal of Cardiology·Senthil K ThambidoraiAllan L Klein
Jan 18, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Maurice M A L PelsersJan F C Glatz
Apr 19, 2008·Internal Medicine·Kunitoshi Iseki
Nov 15, 2008·Journal of the American College of Cardiology·Claudio RoncoRinaldo Bellomo
Feb 14, 2009·Journal of the American College of Cardiology·Wilfried MullensW H Wilson Tang
Jun 12, 2010·The American Journal of Cardiology·Robb D KociolAdrian F Hernandez
Oct 6, 2012·International Heart Journal·Akihiro ShirakabeKyoichi Mizuno
Dec 5, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Akihiro ShirakabeKyoichi Mizuno

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Citations

Oct 4, 2019·Biomarkers in Medicine·Leili PourafkariNader D Nader
Aug 14, 2020·Journal of Clinical Medicine·Barbara InfanteGiovanni Stallone
Nov 27, 2019·Current Heart Failure Reports·Alexander S MangubaAnuradha Lala
Jul 20, 2021·International Heart Journal·Akihiro ShirakabeWataru Shimizu
Oct 20, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Michael A VeraJoe M El-Khoury

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Methods Mentioned

BETA
enzyme‐linked immunosorbent assay
ELISA
X‐ray

Software Mentioned

SPSS

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