Worsening renal function and prognosis in pulmonary hypertension patients hospitalized for right heart failure

Congestive Heart Failure
Lisa M MielniczukRoss A Davies

Abstract

Increased central venous pressures have been associated with the development of worsening renal function (WRF), an important marker of prognosis. We sought to determine the incidence and prognostic significance of WRF in pulmonary hypertension patients (PH) with isolated right HF. A prospective study of PH clinic patients admitted to hospital for right HF. WRF was defined as a rise in creatinine of 26 μmol/L (0.3 mg/dL) within the first 48 hours of admission. A total of 32 patients were enrolled in this study, 67% of patients had moderate-severe chronic kidney disease with an eGFR ≤ 60 mL/min and 34% (n=11) developed WRF during their admission. The mean right atrial pressure was higher in patients with WRF (19 ± 7 mm Hg vs 12 ± 6 mm Hg, P=.05). A total of 36% of patients with WRF died in hospital compared to 5% in the group that did not develop WRF (OR for hospital death 13.3 ± 16, P=.03). The combined endpoint of death or readmission at 6 months was 45% in the WRF group and 43% in the group without WRF (P=.89). Significant renal dysfunction is common in patients with PH and an acute decline in renal function is an important marker of in hospital death and short term mortality in right heart failure.

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Citations

Feb 13, 2015·Critical Care : the Official Journal of the Critical Care Forum·Katie M MuzevichDaniel C Grinnan
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Oct 12, 2018·Current Cardiology Reviews·Mario NaranjoJanani Rangaswami
Sep 6, 2018·The International Journal of Cardiovascular Imaging·Juan Betuel Ivey-MirandaGuillermo Saturno-Chiu

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