Would monolayers provide more representative samples and improved preparations for cervical screening? Overview and evaluation of systems available

Acta Cytologica
E McGoogan, A Reith

Abstract

Conventional cervical smears prepared on site by the smear taker are subject to great variation in technical quality and allow little control of the critical parameters required for optimal microscopic diagnosis. More critical, however, is that a significant proportion of the cells removed from the cervix are discarded along with the collecting device and that the material placed on the slide is not transferred in a representative way and may not fully represent the cells removed from the cervix. If the cells were placed directly into preservative fluid, all the material scraped from the cervix would be sent to the laboratory in a well-preserved state, and fully representative slides could be prepared. Several studies have suggested that this would result in an increased cell harvest with a reduction of inadequate slides and an increase in the detection of abnormal cells. Automated preparation devices are now available. Two such devices, CytoRich and ThinPrep, were recently evaluated at the University of Edinburgh Department of Pathology (UEPD). The operational characteristics of each device were evaluated and consumables costed according to 1993-1994 prices. The consumables for the CytoRich were calculated to be more expensive...Continue Reading

Citations

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