Would sickle cell trait influence the metabolic control in sub-Saharan individuals with type 2 diabetes?

Diabetic Medicine : a Journal of the British Diabetic Association
V AmaEugène Sobngwi

Abstract

To determine the prevalence and effects of sickle cell trait on metabolic control in a Cameroonian diabetic population in a tertiary care setup. This was a cross-sectional study involving 73 consecutive outpatients with Type 2 diabetes recruited from the Yaounde National Diabetes and Obesity Centre. Sickle cell trait status was based on haemoglobin electrophoresis. Metabolic control was assessed by plasma glucose and HbA(1c), and comparisons made between participants with and without sickle cell trait, with adjustment for confounders through linear regressions models. The prevalence of sickle cell trait was 19%, without sex difference, and comparable with figures in individuals without diabetes in this setting. Participants with diabetes and sickle cell trait were older than the non-trait participants (66 vs. 58 years, P = 0.02). Otherwise, clinical and biological profile including indicators of metabolic control were similarly distributed between trait and non-trait participants (all P >0.08). After adjustment for confounders, sickle cell trait was unrelated to fasting glucose (β = 0.02; 95% confidence interval -37.68-43.30) and HbA(1c) (β = -0.03, 95% confidence interval -1.18-0.93), and did not affect the relationship betwee...Continue Reading

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Citations

Oct 23, 2015·International Journal of Endocrinology·S M SeckL Gueye
Mar 23, 2019·Journal of Diabetes Science and Technology·David C Klonoff
Mar 17, 2017·BMC Infectious Diseases·Anastasie Nicole Alima YandaPaul Olivier N Koki

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