Wound chronicity and fibroblast senescence--implications for treatment.

International Wound Journal
Keith G HardingTania J Phillips

Abstract

A proportion of chronic wounds fail to heal in response to standard therapy. For venous leg ulcers, a correlation exists between longer duration before treatment initiation and poor healing response to compression therapy. Differences identified between the healing wound microenvironment and that of the non healing chronic wound suggests that many potential mechanisms exist to impair healing. One contributory mechanism may be inhibition of fibroblast proliferation and induction of a stress-induced premature senescence phenotype by the continuing inflammation found in chronic wounds. Senescent fibroblasts exhibit an extracellular matrix degradative phenotype that contributes to wound chronicity. Accumulation of greater than 15% senescent fibroblasts has been described as a threshold beyond which wounds become hard to heal. The ratio of senescent : non senescent cells is therefore critical to determining response to treatment, and adjunctive therapies that modulate this ratio in favour of non senescent cells are likely to enhance therapeutic healing rates. A number of tissue-engineered dermal replacements contain non senescent fibroblasts and can donate cells to the wound environment additional to releasing growth factors and rev...Continue Reading

References

Nov 11, 1998·Journal of Vascular Surgery·M V MendezJ O Menzoian
Apr 3, 1999·Journal of Wound Care·T J PhillipsH Y Park
Aug 24, 1999·Archives of Dermatology·D J MargolisB L Strom
Jan 13, 2000·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·N J TrengoveG Schultz
Jun 5, 2001·Journal of Vascular Surgery·A Stanley, T Osler
Mar 26, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Gregory S SchultzWolfgang Vanscheidt
Jun 26, 2003·The Surgical Clinics of North America·Kevin J Cross, Thomas A Mustoe
Apr 17, 2004·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·David J MargolisJesse A Berlin
May 4, 2004·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A A OmarS Homer-Vanniasinkam
Sep 21, 2004·The Journal of Biological Chemistry·Jian-Hua ChenC Nicholas Hales
Dec 1, 2004·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M S GohelM R Whyman
Jan 29, 2005·The Journal of Investigative Dermatology·Ching Ching SeahHee-Young Park
Apr 15, 2005·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Dean WilliamsKeith G Harding
Apr 30, 2005·The International Journal of Lower Extremity Wounds·Esther Middelkoop

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Citations

Feb 3, 2011·Seminars in Plastic Surgery·Mark W Clemens, Christopher E Attinger
Mar 7, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Hyun Jung KimJae-Ryong Kim
Jul 23, 2008·Journal of Biomaterials Science. Polymer Edition·Jonathan Mansbridge
Jan 13, 2011·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Luckshman BavanJagdeep Nanchahal
Mar 19, 2014·European Journal of Pharmacology·Anu GopalDinesh Kumar
Jan 8, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Monica De MatteiPaolo Zamboni
May 3, 2012·Critical Care Nursing Clinics of North America·Stephanie R Goldberg, Robert F Diegelmann
Nov 16, 2010·The Surgical Clinics of North America·Markéta Límová
Oct 31, 2007·Clinics in Plastic Surgery·Jaymie Panuncialman, Vincent Falanga
Sep 11, 2007·The Nursing Clinics of North America·Paula E Bermann
Feb 6, 2007·Clinics in Dermatology·Chukwuemeka N Etufugh, Tania J Phillips
Jan 1, 2014·International Wound Journal·Victoria K ShanmugamAnton Wellstein
Jun 4, 2013·Marine Biotechnology·Antoni IbarzDeborah M Power
Apr 30, 2008·Diabetes/metabolism Research and Reviews·R Gary Sibbald, Kevin Y Woo
Jan 9, 2008·International Wound Journal·Lee C RogersDavid G Armstrong
Jan 24, 2008·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Chris Loryman, Jonathan Mansbridge
Apr 1, 2008·Journal of Cellular and Molecular Medicine·Olivera StojadinovicMarjana Tomic-Canic
Sep 3, 2011·Journal of Biomedical Materials Research. Part a·Matthew J CozadSheila A Grant
Jul 28, 2010·International Wound Journal·Elia B RicciCristiana Di Campli
Jan 25, 2011·Journal of Thrombosis and Haemostasis : JTH·A Enzerink, A Vaheri
Jun 10, 2010·International Wound Journal·Christine A Chrisman
Nov 19, 2011·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Ulla StumpfMartin Scholz
Mar 4, 2014·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Harris PratsinisDimitris Kletsas
Mar 1, 2012·Journal of Tissue Engineering and Regenerative Medicine·Christophe HelaryMarie Madeleine Giraud-Guille
Mar 19, 2014·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·David C Bosanquet, Keith G Harding
Dec 17, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Nathan B MenkeUNKNOWN Virginia Commonwealth University Reanimation, Engineering Shock Center, The Wound Healing Group
Jul 10, 2013·International Wound Journal·Keith HardingZee Upton
Jun 17, 2015·The Journal of Investigative Dermatology·James A RoperMark D Bass
Apr 17, 2015·Stem Cell Research & Therapy·Luis Rodriguez-MenocalEvangelos Van Badiavas
Sep 10, 2010·Journal of Vascular Surgery·Rhonda S CornellChristopher E Attinger
Feb 26, 2015·Advances in Wound Care·Lauren Alexis HoeferlinDayanjan Shanaka Wijesinghe
Aug 23, 2016·International Wound Journal·Rhiannon L HarriesKeith G Harding
Jul 13, 2016·Yonsei Medical Journal·Yohanes Widodo WirohadidjojoHardyanto Soebono
Aug 25, 2016·Plastic and Reconstructive Surgery·Ersilia L AnghelChristopher E Attinger
Oct 5, 2010·Phlebology·Andrew W Bradbury
Oct 19, 2007·Toxicologic Pathology·Liora Braiman-WiksmanTamar Tennenbaum
Oct 1, 2013·Journal of Cutaneous Medicine and Surgery·R Gary SibbaldPersaud Reneeka
Nov 27, 2007·Current Problems in Surgery·Michael G FranzMartin C Robson
Jun 27, 2017·Journal of the American Podiatric Medical Association·Lourdes Vella, Cynthia Formosa

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