Wound healing and anti-inflammatory activities induced by a Plantago australis hydroethanolic extract standardized in verbascoside

Journal of Ethnopharmacology
Nathalia Denise de Moura SperottoDinara Jaqueline Moura

Abstract

Plantago australis is a popular plant found to be widely spread in Latin America. In folk medicine, the seeds and leaves are used mainly for anti-inflammatory, wound healing, among others. The verbascoside, a phenolic glycoside, is an active chemical component described in this species of plant, which has antioxidant, anti-inflammatory and healing effects. The aim of the present study was to evaluate whether P. australis hydroethanolic extract (PAHE) standardized in verbascoside could promote wound healing associated with anti-inflammatory action within both in vitro and in vivo models. For the wound healing activity, we used a Scratch Test, an assay capable of evaluating the migratory ability of keratinocyte cells (HaCat) in vitro and thereby confirming the activity in rats. For the anti-inflammatory activity, the inflammation was induced with LPS in microglial murine cells (N9). Inflammatory mediators (IL-6, IL-10, IL-12p70, INFγ, MCP-1 and TNFα) were measured and the activity of superoxide dismutase (SOD), catalase (CAT), and mitochondrial membrane potential were evaluated. In addition, using paw edema induced by carrageenan in rats, the anti-inflammatory activity in vivo was analyzed. The PAHE and verbascoside, induced a si...Continue Reading

Citations

Apr 9, 2020·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·F Tugce Guragac DereliEsra Kupeli Akkol
Feb 12, 2020·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Andiamira Cagnoni BalestraMarcos C Borges
May 28, 2019·International Journal of Molecular Sciences·Chang-Chih ChenHaw-Ming Huang
Nov 13, 2019·Phytotherapy Research : PTR·Tatiane Roquete AmparoGustavo Henrique Bianco de Souza
Feb 13, 2021·Plants·Milton Abraham Gómez-HernándezMaría Elena Estrada-Zúñiga
May 10, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nathalia D de Moura SperottoPablo Machado
Jun 13, 2021·Macromolecular Bioscience·Xiaohan SuJun Wu
Nov 14, 2021·Comprehensive Reviews in Food Science and Food Safety·Joana MadureiraLillian Barros

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