Wound healing and infection in surgery: the pathophysiological impact of smoking, smoking cessation, and nicotine replacement therapy: a systematic review

Annals of Surgery
Lars Tue Sørensen

Abstract

The aim was to clarify how smoking and nicotine affects wound healing processes and to establish if smoking cessation and nicotine replacement therapy reverse the mechanisms involved. Smoking is a recognized risk factor for healing complications after surgery, but the pathophysiological mechanisms remain largely unknown. Pathophysiological studies addressing smoking and wound healing were identified through electronic databases (PubMed, EMBASE) and by hand-search of articles' bibliography. Of the 1460 citations identified, 325 articles were retained following title and abstract reviews. In total, 177 articles were included and systematically reviewed. Smoking decreases tissue oxygenation and aerobe metabolism temporarily. The inflammatory healing response is attenuated by a reduced inflammatory cell chemotactic responsiveness, migratory function, and oxidative bactericidal mechanisms. In addition, the release of proteolytic enzymes and inhibitors is imbalanced. The proliferative response is impaired by a reduced fibroblast migration and proliferation in addition to a downregulated collagen synthesis and deposition. Smoking cessation restores tissue oxygenation and metabolism rapidly. Inflammatory cell response is reversed in pa...Continue Reading

References

Mar 23, 1978·The New England Journal of Medicine·B M Babior
Mar 1, 1979·Infection and Immunity·J CorberandB Gleizes
Sep 1, 1975·Infection and Immunity·R C Noble, B B Penny
Nov 1, 1992·Experimental Lung Research·C SelbyW MacNee
Sep 1, 1991·Archives of Surgery·J A JensenT K Hunt
May 1, 1989·Journal of Applied Physiology·V Mohsenin, J L Gee
Jan 1, 1987·Annals of the New York Academy of Sciences·E Niki
Jul 1, 1986·Journal of Leukocyte Biology·R B Bridges, L Hsieh
Jan 1, 1987·Archives of Environmental Health·D Richardson
Nov 1, 1986·Anesthesia and Analgesia·J R KambamS A Hyman
Jun 1, 1985·Plastic and Reconstructive Surgery·S Craig, T D Rees
Aug 1, 1985·British Journal of Pharmacology·J Grayson, D D Oyebola
Sep 2, 1974·JAMA : the Journal of the American Medical Association·C L SarinW O Nickel
Jan 1, 1984·Respiration; International Review of Thoracic Diseases·D VanuxemC Grimaud
Jan 1, 1983·European Journal of Applied Physiology and Occupational Physiology·K KlausenS Nandrup
Apr 1, 1984·Journal of the American College of Cardiology·L W KleinL E Teichholz
Apr 1, 1984·British Journal of Plastic Surgery·W T LawrenceJ P Heggers
Jul 1, 1981·Plastic and Reconstructive Surgery·R F DiegelmannA M Kaplan
Mar 1, 1995·Clinical and Experimental Pharmacology & Physiology·T G PickeringG D James
May 1, 1995·American Journal of Respiratory and Critical Care Medicine·Y NakamuraS I Rennard
Jan 1, 1994·The Journal of Hand Surgery·R MorecraftR H Gable
Jun 1, 1993·Drug and Alcohol Dependence·J E HenningfieldE D London
Jul 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·P Rojanapongpun, S M Drance
Jul 13, 1996·BMJ : British Medical Journal·J LykkesfeldtH E Poulsen
Oct 15, 1996·American Journal of Epidemiology·J SunyerJ M Samet
Apr 1, 1997·The American Journal of Clinical Nutrition·J LykkesfeldtH E Poulsen
May 1, 1997·Hypertension·M Hausberg, V K Somers
Jun 1, 1997·Journal of the American College of Cardiology·N L Benowitz, S G Gourlay
Jul 1, 1997·Journal of the American College of Cardiology·J J MahmarianC M Pratt
Sep 25, 1997·Archives of Surgery·D B AllenT K Hunt

❮ Previous
Next ❯

Citations

Oct 30, 2013·Plastic and Reconstructive Surgery·Amy Anne D LassigAnne M Joseph
Jul 31, 2014·Journal of the American Podiatric Medical Association·Jon M HumphersDaniel Jupiter
Jan 30, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Rik C NelissenMyrthe K S Hol
Aug 14, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Louis G Mercuri
Dec 15, 2015·Orthopedics·Andrew P SchannenGregory L DeSilva
Sep 13, 2013·Orthopedics·Alexandria StarksJohn A Abraham
Sep 19, 2014·The Journal of Oral Implantology·Ghadeer ThaljiSalvador Nares
Apr 23, 2015·British Journal of Anaesthesia·A KurzUNKNOWN Factorial Trial Investigators
Jun 24, 2015·International Journal of Colorectal Disease·Maziar NikbergKenneth Smedh
Mar 4, 2015·The Journal of Laryngology and Otology·E RiojaI Vilaseca
Apr 29, 2015·Microvascular Research·Itay Bentov, May J Reed
May 25, 2016·Aesthetic Surgery Journal·Ashkan AfshariK Kye Higdon
Mar 29, 2014·Revista da Escola de Enfermagem da U S P·Barbara Vieira CavichioLídia Aparecida Rossi
Dec 22, 2016·The Laryngoscope·Samuel N HelmanRaymond L Chai
Jan 4, 2017·The Journal of Craniofacial Surgery·Burhan Özalp, Çağri Çakmakoğlu
Dec 4, 2016·Physical Medicine and Rehabilitation Clinics of North America·Francesco CarliBradford Hirsch
Nov 24, 2016·Plastic and Reconstructive Surgery·Peter J Taub, Alan Matarasso
Feb 25, 2017·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·U AlkanG Bachar
Apr 10, 2017·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Christopher M YaoJohn R de Almeida
Sep 18, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Robert G MartindaleChristy M Lawson
May 27, 2014·The American Journal of Sports Medicine·Juan Santiago-TorresJulie Y Bishop
Nov 9, 2017·International Journal of Environmental Research and Public Health·Sam McCrabbBillie Bonevski
Mar 22, 2018·British Journal of Nursing : BJN·Peter Ellis
Dec 17, 2017·Hernia : the Journal of Hernias and Abdominal Wall Surgery·L ClayK Strigård
Sep 6, 2017·Hernia : the Journal of Hernias and Abdominal Wall Surgery·I Khansa, J E Janis
Jun 24, 2017·Journal of Neurosurgery·John FutchkoB Gregory Thompson
Jan 31, 2018·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Robert Svensson-BjörkStefan Acosta
Aug 1, 2013·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Lela MigirovMichael Wolf
May 23, 2018·The British Journal of Dermatology·A Ferris, K Harding
Oct 19, 2017·Hernia : the Journal of Hernias and Abdominal Wall Surgery·N A HenriksenF E Muysoms
Dec 9, 2017·Diseases of the Colon and Rectum·Vladimir BolshinskyAlexander Heriot
Mar 13, 2018·Diseases of the Colon and Rectum·Tatiana CatanzariteMarianna Alperin
Dec 1, 2015·AORN Journal·Heather Hohenberger, Kim Delahanty
Nov 6, 2014·Journal of Surgical Oncology·Ibrahim Khansa, Jeffrey E Janis
Aug 23, 2018·Obstetrics and Gynecology·UNKNOWN Committee on Gynecologic Practice
Sep 29, 2018·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Tomoya SatoShigeru Ichioka
Oct 23, 2018·JAMA Facial Plastic Surgery·Meghan M CrippenRichard Chan Woo Park
Oct 10, 2018·Journal of Diabetes Investigation·Nan XiaAiping Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved