Wound healing effect of bioactive ion released from Mg-smectite

Materials Science & Engineering. C, Materials for Biological Applications
Yu SasakiOsamu Yamamoto

Abstract

Bioactive ions like Mg(2+) and Si(4+) have been known as promotion factors of tissue regeneration. In the present work, Mg-smectite, consisting of Mg(2+) and Si(4+) ions, was synthesized by a solution process, and evaluated for the efficiency of the powder on wound healing in rats. White precipitates were obtained by mixing a magnesium chloride hexahydrate solution and a sodium silicate hexahydrate solution at room temperature. The precipitates mixed with a NaOH aqueous solution were subjected to hydrothermal reaction, and finally crystalline Mg-smectite powder was obtained. The crystal and molecular structure of Mg-smectite was identified by X-ray diffractometry (XRD) and Fourier-transform infrared spectroscopy (FT-IR). The synthesized material was determined to be crystalline Mg-smectite. The amount of Mg(2+) and Si(4+) ions released from Mg-smectite in physiological saline was analyzed by inductively coupled plasma mass spectroscopy (ICP-MS). The total amount of Si(4+) ion released from Mg-smectite was greater than that of Mg(2+) ion. To evaluate the wound healing effect of Mg-smectite, Mg-smectite powder was applied to a full-thickness surgical wound reaching the subcutaneous tissue in the rat's abdomen. At 1 and 2weeks, sk...Continue Reading

Citations

Apr 21, 2018·International Journal of Biometeorology·Jose Manuel Carbajo, Francisco Maraver
May 28, 2020·Pharmaceutics·Fátima García-VillénGiuseppina Sandri
Apr 9, 2020·Frontiers in Bioengineering and Biotechnology·Fengxuan HanBin Li
Dec 16, 2020·ACS Biomaterials Science & Engineering·Tina MehrabiZahra Mohammadi

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