Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil.

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Lea CastellucciJenefer M Blackwell

Abstract

Leishmania braziliensis causes cutaneous (CL) and mucosal (ML) leishmaniasis. In the mouse, Fli1 was identified as a gene influencing enhanced wound healing and resistance to CL caused by Leishmania major. Polymorphism at FLI1 is associated with CL caused by L. braziliensis in humans, with an inverse association observed for ML disease. Here we extend the analysis to look at other wound healing genes, including CTGF, TGFB1, TGFBR1/2, SMADS 2/3/4/7 and FLII, all functionally linked along with FLI1 in the TGF beta pathway. Haplotype tagging single nucleotide polymorphisms (tag-SNPs) were genotyped using Taqman technology in 325 nuclear families (652 CL cases; 126 ML cases) from Brazil. Robust case-pseudocontrol (CPC) conditional logistic regression analysis showed associations between CL and SNPs at CTGF (SNP rs6918698; CC genotype; OR 1.67; 95%CI 1.10-2.54; P=0.016), TGFBR2 (rs1962859; OR 1.50; 95%CI 1.12-1.99; P=0.005), SMAD2 (rs1792658; OR 1.57; 95%CI 1.04-2.38; P=0.03), SMAD7 (rs4464148; AA genotype; OR 2.80; 95%CI 1.00-7.87; P=0.05) and FLII (rs2071242; OR 1.60; 95%CI 1.14-2.24; P=0.005), and between ML and SNPs at SMAD3 (rs1465841; OR 2.15; 95%CI 1.13-4.07; P=0.018) and SMAD7 (rs2337107; TT genotype; OR 3.70; 95%CI 1.27-10....Continue Reading

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Citations

Jul 23, 2013·PLoS Neglected Tropical Diseases·Yahya SohrabiMarie Lipoldová
Jan 7, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Lucas AlmeidaLéa Castellucci
Oct 3, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·V D Mangano, D Modiano
Feb 13, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M-A HartleyN Fasel
May 8, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jason L WeiratherMary E Wilson
Jun 9, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Chao YanKui-Yang Zheng
Jul 22, 2016·Parasitology·Glênia Daros SarnágliaDaniel Cláudio Oliviera Gomes
May 28, 2014·Memórias do Instituto Oswaldo Cruz·Léa Cristina CastellucciJenefer Mary Blackwell
Jun 21, 2017·International Journal of Molecular Sciences·Breanna M ScorzaMary E Wilson
Jul 20, 2018·Parasitology Research·Felipe Dutra RêgoCélia Maria Ferreira Gontijo
Feb 15, 2020·Human Genetics·Jenefer M BlackwellLéa C Castellucci
Mar 5, 2020·Memórias do Instituto Oswaldo Cruz·Anadilton Santos da HoraLéa Cristina Castellucci
Aug 25, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Léa C CastellucciJenefer M Blackwell
Dec 29, 2020·Experimental and Molecular Pathology·Kamil BujakTadeusz Osadnik
Mar 23, 2021·Expert Review of Clinical Immunology·Daniele Stéfanie Sara Lopes Lera-NonoseMaria Valdrinez Campana Lonardoni

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