Wound healing in cutaneous leishmaniasis: A double edged sword of IL-10 and TGF-β

Comparative Immunology, Microbiology and Infectious Diseases
Amir AbdoliFatemeh Ghaffarifar

Abstract

Immune responses have a crucial role during the wound healing process in cutaneous leishmaniasis (CL). However, there are several paradoxes in immunity against CL. On the one hand, regulatory cytokines interleukin (IL)-10 and transforming growth factor beta (TGF-β) increase susceptibility to CL through suppression of several proinflammatory cytokines that require for defense against CL. On the other hand, these cytokines play a pivotal role in the acceleration of wound healing process. This review discusses about the dual role of IL-10 and TGF-β during the wound healing process and immunity against CL to offer a new insight about wound healing in CL.

Citations

Sep 29, 2020·Frontiers in Microbiology·Flávia de Oliveira CardosoKátia da Silva Calabrese
Jan 7, 2021·Biological Trace Element Research·Ali TaghipourEzatollah Ghasemi
Apr 8, 2021·Parasitology Research·Santanu Sasidharan, Prakash Saudagar
May 1, 2021·International Journal of Molecular Sciences·Giuliana ManninoDebora Lo Furno
May 25, 2021·Parasite Immunology·Abdollah JafarzadehBhaskar Saha
Oct 5, 2021·Parasitology Research·Mahshid MostafaviAli Karamoozian

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