PMID: 9421851Jan 9, 1998Paper

Wound healing in sepsis and trauma

Shock
F J ThorntonAdrian Barbul

Abstract

Wound healing represents a dynamic and immediate response of the body to tissue injury with the purpose of restoring anatomical continuity, structure and function. Success or failure of this complex cascade of events is determined largely by competence of the host's immune system. Sepsis represents one of the most formidable threats to successful wound healing. It can present as a local bacterial colonization of the injury site with minimal systemic reaction or the "systemic inflammatory response syndrome," a primary cause of mortality among critically ill patients. Trauma also predisposes patients to wound complications especially as a result of post-traumatic immunosuppression. This phenomenon exposes the patient to the risk of microbial infection and ultimately the sepsis syndrome. The immune system, therefore, represents a vulnerable gateway through which trauma and sepsis exert their deleterious effect on the wound healing process resulting in increased morbidity and mortality for the surgical patient.

Citations

Dec 22, 2000·Contraception·D M PhillipsR A Maguire
Dec 17, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H TapieroK D Tew
Jun 20, 2003·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·D A McNamaraDavid J Bouchier-Hayes
May 16, 2000·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·J StammT C Vary
Aug 9, 2003·Critical Care Medicine·Maria B Witte, Adrian Barbul
Jun 27, 2006·Plastic and Reconstructive Surgery·Meghan Arnold, Adrian Barbul
Nov 20, 2002·The Journal of Clinical Investigation·Wouter J de JongeWouter H Lamers
Apr 26, 2008·PLoS Computational Biology·Yoram VodovotzGary An
Jul 27, 2001·Clinical and Experimental Immunology·C GouttefangeasJ Pinocy
Jan 26, 2016·The Spine Journal : Official Journal of the North American Spine Society·Sleiman HaddadAlexander R Vaccaro
May 3, 2012·Critical Care Nursing Clinics of North America·Jeremy Z Williams, Adrian Barbul
Jun 16, 2009·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Agata Cieslik-BieleckaTomasz Szczepanski
Jun 20, 2015·The Journal of Trauma and Acute Care Surgery·Amy V GoreZiad C Sifri
May 12, 2015·Bone·Jonathan M KarnesColleen M Watkins
Feb 7, 2002·The Journal of Surgical Research·Rebeca M RicoLuisa A DiPietro
Oct 18, 2016·Journal of Neurotrauma·Jessica M MarbourgPhillip G Popovich
May 4, 2005·The International Journal of Lower Extremity Wounds·N PetrieP Banwell
Mar 16, 2017·Orthopedics·Turan Cihan Dülgeroglu, Hasan Metineren
Nov 27, 2007·Current Problems in Surgery·Michael G FranzMartin C Robson
Apr 5, 2020·Drug Testing and Analysis·Sylvia I MeierStefan W Toennes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.