Wound healing of metastatic perineal Crohn's disease using hyperbaric oxygen therapy: A case series.

United European Gastroenterology Journal
C A LansdorpR A van Hulst

Abstract

Metastatic Crohn's disease (CD) is a rare manifestation of CD. It involves inflammatory skin lesions with histopathological findings (granulomas) similar to CD, without connection to the gastrointestinal tract. Hyperbaric oxygen therapy (HBO) has been suggested as a possible treatment option. This study aimed to identify and treat a consecutive series of patients with biopsy-proven metastatic CD and monitor wound healing using prospectively acquired outcomes. Pathology results of all patients with ongoing perineal wound-healing problems after proctectomy between 2005 and 2018 at the Amsterdam University Medical Centre were assessed for metastatic CD. Patients with a biopsy-proven diagnosis of perineal metastatic CD were offered HBO (40 daily sessions of 100% oxygen at 2.4 atmosphere absolute). Wound healing was monitored using photographs and standardised questionnaires (the Inflammatory Bowel Disease Questionnaire, EuroQol Visual Analogue Scale and the Female Sexual Function Index) at baseline and 1 and 3 months after HBO. Out of 13 patients in the cohort with persisting perineal wounds after proctectomy, six (46%) had biopsy results consistent with metastatic CD. Of these, three accepted treatment with HBO. All three patients...Continue Reading

References

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Sep 12, 2018·Journal of Crohn's & Colitis·E Joline de GroofChristianne J Buskens

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Citations

Jul 21, 2020·United European Gastroenterology Journal·C A Lansdorp, R A van Hulst
Mar 25, 2021·Journal of Cosmetic Dermatology·Hayson Chenyu WangXiaojun Wang
May 18, 2021·Gastroenterology Research and Practice·Marley R FeitosaOmar Féres
Oct 30, 2021·Advances in Wound Care·Kunal M KirloskarChristopher E Attinger
Jan 11, 2022·United European Gastroenterology Journal·Alessandro Armuzzi, Daniela Pugliese
Apr 28, 2021·European Journal of Gastroenterology & Hepatology·Anupam Kumar SinghVishal Sharma

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Methods Mentioned

BETA
biopsy
surgical resection
biopsies

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