Wound Healing Outcomes and Health-Related Quality-of-Life Changes in the ACHILLES Trial: 1-Year Results From a Prospective Randomized Controlled Trial of Infrapopliteal Balloon Angioplasty Versus Sirolimus-Eluting Stenting in Patients With Ischemic Peripheral Arterial Disease

JACC. Cardiovascular Interventions
Konstantinos KatsanosDierk Scheinert

Abstract

The authors sought to report the wound healing outcomes, health-related quality-of-life changes and quality-adjusted life-years (QALYs) gain in the 2 treatment arms of the ACHILLES (Comparing Angioplasty and DES in the Treatment of Subjects With Ischemic Infrapopliteal Arterial Disease) multicenter randomized trial. The ACHILLES randomized trial has previously shown that sirolimus-eluting stents (SES) may achieve lower vessel restenosis and higher event-free survival rates compared with plain balloon angioplasty (PTA) for infrapopliteal lesions. A total of 200 patients were randomly assigned between SES and PTA for the treatment of infrapopliteal arterial occlusive lesions. Progression of wound healing was serially assessed by digital photography. Health-related quality-of-life scores were assessed with the self-administered EQ-5D questionnaire up to 1 year from randomization. QALYs gained were calculated with a standard multiplicative model using distribution-free Bayesian modeling. In total, 109 open wounds (n = 54 in SES; n = 55 in PTA) were documented at baseline. At 6 months, wound volume reduction (%) was significantly higher in the SES group (95% healing [95% confidence interval (CI): 80% to 99%] compared with 60% healin...Continue Reading

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Citations

Jan 20, 2017·Vascular and Endovascular Surgery·Alessia GiaquintaPierfrancesco Veroux
Feb 16, 2019·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Lisa Gould, William W Li
Feb 2, 2019·World Journal of Cardiology·Stavros SpiliopoulosElias Brountzos
Jul 4, 2018·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Konstantinos StavroulakisUNKNOWN CRITISCH Collaborators
Dec 5, 2018·World Journal of Cardiology·Stavros SpiliopoulosElias N Brountzos
Dec 12, 2018·The Cochrane Database of Systematic Reviews·Charlie C-T HsuMieke L van Driel
Apr 7, 2021·Nature Biomedical Engineering·Shiqi HuKe Cheng

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