Wound-healing response and refractive regression after conductive keratoplasty

Journal of Cataract and Refractive Surgery
Salomon EsquenaziHaydee E P Bazan

Abstract

To characterize the histological changes that occur after conductive keratoplasty (CK) using a rabbit model. LSU Eye Center and Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, Louisiana, USA. Conductive keratoplasty was performed on 24 eyes of 12 New Zealand albino rabbits. In each eye, 24 spots were placed in a cross-corneal manner using 3 optical zones at 6.0, 7.0, and 8.0 mm. Eyes were assessed with corneal topography weekly. Rabbits were humanely killed 2, 4, 6, and 8 weeks postoperatively. The eyes were then enucleated and processed for histopathology and immunohistochemical analysis. All eyes showed an initial mean steepening of the corneal curvature of 2.24 diopters (D) 2 weeks postoperatively. Corneal topography revealed a 26%, 36%, and 39% regression of the refractive results at 4, 6, and 8 weeks, respectively. Immunohistochemical analysis demonstrated keratocyte apoptosis, myofibroblast appearance, and upregulation of chondroitin sulfate, MMP-1, and collagen III in the area surrounding the tip in each spot. The histological changes that occur after CK may be responsible for the well-established regression of its refractive effect. A better understa...Continue Reading

References

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Jan 8, 2004·Journal of Cataract and Refractive Surgery·Danny Y Lin, Edward E Manche
Apr 20, 2004·Journal of Cataract and Refractive Surgery·Salomon EsquenaziNicolas G Bazan
Jan 27, 2005·Investigative Ophthalmology & Visual Science·Paulo OttinoHaydee E P Bazan

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Citations

Jul 20, 2010·Biomechanics and Modeling in Mechanobiology·M FraldiF Guarracino
Sep 18, 2010·Cornea·Yin Dong FangHuang Yi Fei
Jun 15, 2007·Current Opinion in Ophthalmology·Ted T DuPenny A Asbell
Oct 12, 2012·Clinical Ophthalmology·André Am TorricelliSamir J Bechara
Mar 29, 2014·Middle East African Journal of Ophthalmology·Pandelis A Papadopoulos, Alexandros P Papadopoulos
May 25, 2010·Journal of Cataract and Refractive Surgery·Mohammad Ghassan AyoubiTara C B Moore
Aug 18, 2009·Journal of Cataract and Refractive Surgery·Jason S Ehrlich, Edward E Manche
Jul 11, 2018·Journal of Current Ophthalmology·Mehrdad MohammadpourHassan Hashemi
Mar 11, 2017·Journal of Ophthalmology·Menglei WangZhiyu Du
Jun 15, 2007·Current Opinion in Ophthalmology

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