Wound tissue can utilize a polymeric template to synthesize a functional extension of skin

Science
I V YannasE M Skrabut

Abstract

Prompt and long-term closure of full-thickness skin wounds is guinea pigs and humans is achieved by applying a bilayer polymeric membrane. The membrane comprises a top layer of a silicone elastomer and a bottom layer of a porous cross-linked network of collagen and glycosaminoglycan. The bottom layer can be seeded with a small number of autologous basal cells before grafting. No immunosuppression is used and infection, exudation, and rejection are absent. Host tissue utilizes the sterile membrane as a culture medium to synthesize neoepidermal and neodermal tissue. A functional extension of skin over the entire wound area is formed in about 4 weeks.

References

Nov 1, 1975·Journal of Biomedical Materials Research·I V YannasP L Gordon
Jul 1, 1976·The Journal of Investigative Dermatology·M PruniérasM Regnier
May 1, 1974·The Journal of Trauma·J F BurkeW C Quinby
Sep 1, 1971·Annals of Surgery·C C Bondoc, J F Burke
Jan 1, 1980·Journal of Biomedical Materials Research·I V Yannas, J F Burke
Mar 1, 1980·Journal of Biomedical Materials Research·I V YannasR H Rubenstein
Jul 1, 1980·Journal of Biomedical Materials Research·N DagalakisI V Yannas

❮ Previous
Next ❯

Citations

Jan 1, 1996·Journal of Biomedical Materials Research·J C GeesinR A Berg
Apr 5, 1994·Biotechnology and Bioengineering·J F CavallaroK H Kraus
Jul 1, 1992·Journal of Applied Biomaterials : an Official Journal of the Society for Biomaterials·Y KuroyanagiN Shioya
Jun 19, 2001·Journal of Biomedical Materials Research·H SchoofG Rau
Dec 1, 1991·Journal of Biomedical Materials Research·H KobayashiY Ikada
Dec 1, 1992·Journal of Biomedical Materials Research·T Okada, Y Ikada
Jul 1, 1993·Journal of Biomedical Materials Research·B D Ratner
Nov 16, 2004·Journal of Biomedical Materials Research. Part a·Brett R DowningGeorge D Pins
Oct 1, 1994·Journal of Cellular Biochemistry·I V Yannas
Jan 1, 1992·Cytotechnology·R T TranquilloA G Moon
Jun 1, 2000·Medical & Biological Engineering & Computing·B Chevallay, D Herbage
Jan 1, 1991·Annals of Biomedical Engineering·R M Nerem
Jul 1, 1992·Medical & Biological Engineering & Computing·R M Nerem
Dec 14, 1999·Aesthetic Plastic Surgery·H MizunoE Uchinuma
Jan 24, 2008·Biomedical Microdevices·Curtis D ChinSamuel K Sia
Apr 12, 2012·Journal of Materials Science. Materials in Medicine·R KrishnanS Ramakrishna
Jun 18, 2009·In Vitro Cellular & Developmental Biology. Animal·Tara PouyaniNancy L Parenteau
Feb 1, 1991·British Journal of Plastic Surgery·K MatsudaY Ikada
Jul 1, 1990·Biomaterials·S SuzukiY Ikada
Nov 1, 1992·Journal of Dermatological Science·N C Krejci, J McGuire
Nov 19, 2003·Advanced Drug Delivery Reviews·Zbigniew Ruszczak
May 26, 2005·Biomaterials·Yi HongJiacong Shen
Mar 15, 2003·Clinics in Plastic Surgery·Michael J Miller, Charles W Patrick
Jul 23, 1999·International Journal of Biological Macromolecules·S F WilliamsO P Peoples
May 5, 2001·Biomaterials·K UlubayramN Hasirci
Jul 12, 2002·Biomaterials·Kelly R KirkerGlenn D Prestwich
Apr 16, 2003·Biomaterials·Giovanni VozziSangeeta Bhatia
Mar 1, 1995·Trends in Biotechnology·H A NavsariaI A McKay
Jan 1, 1988·Collagen and Related Research·J M McPhersonD G Wallace
Apr 20, 1999·Burns : Journal of the International Society for Burn Injuries·R L Sheridan, R G Tompkins

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.