Wounds as the Portal of Entrance for Parrot Bornavirus 4 (PaBV-4) and Retrograde Axonal Transport in Experimentally Infected Cockatiels (Nymphicus hollandicus).

Avian Diseases
Julia HeckmannMichael Lierz

Abstract

In this study, we investigated the natural route of infection of psittacine bornavirus (PaBV), which is the causative agent of proventricular dilatation disease (PDD) in psittacines. We inoculated two infection groups through wounds with a PaBV-4 isolate. In nine cockatiels (Nymphicus hollandicus) we applied a virus suspension with a titer of 103 50% tissue culture infection dose (TCID50) via palatal lesions (Group P, P1-9). In a second group of three cockatiels, we applied a virus suspension with a titer of 104 TCID50 to footpad lesions (Group F, F1-3). In two cockatiels, the control (or "mock") group, we applied a virus-free cell suspension (Group M, M1-2) via palatal lesions. The observation period was 6 mo (Groups P and M) or 7 mo (Group F). We monitored PaBV-4 RNA shedding and seroconversion. At the end of the study, we examined the birds for the presence of inflammatory lesions, PaBV-4 RNA, and antigen in tissues, as well as virus reisolation of brain and crop material. We did not observe any clinical signs typical of PDD during this study. We also did not see seroconversion or PaBV RNA shedding in any bird during the entire investigation period, and virus reisolation was not successful. We only found PaBV-4 RNA in sciati...Continue Reading

References

Jan 1, 1980·Medical Microbiology and Immunology·S Herzog, R Rott
Jan 1, 1996·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·C R GregoryB W Ritchie
Aug 8, 2008·The Journal of Small Animal Practice·A SteinmetzG Oechtering
Dec 3, 2008·Emerging Infectious Diseases·Kirsi S HonkavuoriW Ian Lipkin
Oct 1, 2001·Avian Pathology : Journal of the W.V.P.A·Y BerhaneB Hunter
Oct 1, 2009·Emerging Infectious Diseases·Herbert WeissenböckNorbert Nowotny
Mar 6, 2010·Emerging Infectious Diseases·Patricia GrayIan Tizard
Mar 12, 2010·Journal of Virology·Peter StaeheliBernd Kaspers
Apr 16, 2010·Journal of Clinical Microbiology·Sibylle HerzogChristiane Herden
Jul 14, 2010·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Raj RaghavDale A Smith
Aug 5, 2010·The Veterinary Clinics of North America. Exotic Animal Practice·Sharman HoppesIan Tizard
Dec 17, 2011·Emerging Infectious Diseases·Michael LierzDirk Enderlein
Feb 7, 2012·Emerging Infectious Diseases·Anne K PiepenbringMichael Lierz
Nov 20, 2012·Journal of Avian Medicine and Surgery·Erin MonacoIan Tizard
Dec 21, 2012·Animal Health Research Reviews·Susan L PayneDale A Smith
May 2, 2013·Veterinary Microbiology·Dennis RubbenstrothPeter Staeheli
Aug 2, 2014·Current Protocols in Microbiology·Jianhua GuoPaulette Suchodolski
Nov 25, 2014·Emerging Infectious Diseases·Nuri Encinas-NagelMichael Lierz
Dec 3, 2014·Archives of Virology·Jens H KuhnNorbert Nowotny
Dec 4, 2014·Veterinary Microbiology·Natalia A PhiladelphoAntonio J Piantino Ferreira
Apr 23, 2016·Avian Pathology : Journal of the W.V.P.A·Anne K PiepenbringMichael Lierz
Mar 17, 2017·Avian Diseases·Julia HeckmannMichael Lierz
Jun 16, 2012·Veterinary Medicine·J Jill Heatley, Alice R Villalobos

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Citations

Apr 7, 2021·Journal of Wildlife Diseases·Michelle SutherlandMichael Lierz

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