Writing errors as a result of frontal dysfunction in Japanese patients with amyotrophic lateral sclerosis.

Journal of Neurology
Sachiko Tsuji-AkimotoHidenao Sasaki

Abstract

Loss of communication is a critical problem for advanced amyotrophic lateral sclerosis (ALS) patients. This loss of communication is mainly caused by severe dysarthria and disability of the dominant hand. However, reports show that about 50% of ALS patients have mild cognitive dysfunction, and there are a considerable number of case reports on Japanese ALS patients with agraphia. To clarify writing disabilities in non-demented ALS patients, eighteen non-demented ALS patients and 16 controls without neurological disorders were examined for frontal cognitive function and writing ability. To assess writing errors statistically, we scored them on their composition ability with the original writing error index (WEI). The ALS and control groups did not differ significantly with regard to age, years of education, or general cognitive level. Two patients could not write a letter because of disability of the dominant hand. The WEI and results of picture arrangement tests indicated significant impairment in the ALS patients. Auditory comprehension (Western Aphasia Battery; WAB IIC) and kanji dictation also showed mild impairment. Patients' writing errors consisted of both syntactic and letter-writing mistakes. Omission, substitution, dis...Continue Reading

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Citations

Aug 28, 2014·Behavioural Neurology·Kentarou YoshizawaMari Higashikawa
Feb 17, 2015·Journal of Neurology·A TruiniM Inghilleri
Jan 10, 2012·Journal of the Neurological Sciences·Ichiro YabeHidenao Sasaki
Mar 17, 2012·Annals of Medicine·Tim Van LangenhoveChristine Van Broeckhoven
Dec 18, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Toru SakuraiSatoshi Kuwabara
Aug 17, 2019·Journal of the Neurological Sciences·Kazuaki NagashimaYoshio Ikeda

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