PMID: 2503481Aug 1, 1989Paper

WS-9659 A and B, novel testosterone 5 alpha-reductase inhibitors isolated from a Streptomyces. III. Biological characteristics and pharmacological characteristics

The Journal of Antibiotics
O NakayamaM Kohsaka

Abstract

WS-9659 A, a novel phenazine, produced by a Streptomyces sp., had testosterone 5 alpha-reductase inhibition activity on rat, dog and human prostates. However, WS-9659 A did not show any inhibitory activities for aldose reductase on rabbit lenses and lactate dehydrogenase on pig hearts. WS-9659 A was a competitive inhibitor against testosterone 5 alpha-reductase on rat prostates by use of testosterone as a substrate. Radio receptor binding assay of androgen receptor of rat prostates revealed that WS-9659 A had no affinity for this receptor. WS-9659 A was tested subcutaneously in immature castrated rats to confirm its effect on the growth of the ventral prostates induced by testosterone propionate.

Citations

Feb 18, 2012·Natural Product Reports·A CimminoR Kiss
Jul 1, 2010·The Journal of Antibiotics·Kazuhiko OtoguroSatoshi Omura
Mar 14, 2012·Marine Drugs·Tamara P KondratyukJohn M Pezzuto
Dec 26, 2012·Journal of Acupuncture and Meridian Studies·Mijeong BaeYong-ung Kim
Aug 29, 2019·Organic Letters·Haruki KohatsuKouji Kuramochi
Nov 3, 2020·ACS Omega·Haruki KohatsuKouji Kuramochi

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