Wulfenia carinthiaca Jacq., antioxidant and pharmacological activities

Zeitschrift Für Naturforschung. C, a Journal of Biosciences
Rinaldo CervellatiHermann Stuppner

Abstract

Relative antioxidant activities of a methanolic extract of three phenylpropanoid glycosides and three iridoid glycosides from Wulfenia carinthiaca were evaluated using the Briggs-Rauscher (BR) reaction method. This method is based on the inhibitory effects by antioxidants on oscillations of the BR reaction. The total extract showed a certain antioxidant activity with respect to resorcinol chosen as standard. The three phenylpropanoid glycosides showed a very high relative antioxidant activity while iridoid glycosides had practically no activity. These experimental results were confirmed by empirical calculations based on the BDE (Bond Dissociation Enthalpy) theory. The total phenolic content was also measured for the phenylpropanoid glycosides using the Folin-Ciocalteu reagent. The obtained values as gallic acid equivalents were in perfect agreement with the relative antioxidant activities. From a pharmacological point of view the results obtained demonstrate that the methanolic extract of W. carinthiaca have antinociceptive and antiedematogenic effects in the different models adopted. The plant extract produced a significant inhibition, dose related, of the rat paw edema induced by carrageenin. The anti-inflammatory activity i...Continue Reading

Citations

Feb 1, 2006·Journal of Ethnopharmacology·Ester SperoniHermann Stuppner
May 2, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Yu ZhangYanping Tian
Jun 19, 2012·Acta Pharmacologica Sinica·Yuan GuQiang Yu
Sep 9, 2009·Journal of Medicinal Food·Stefano Dall'AcquaGabbriella Innocenti
Feb 15, 2011·Journal of Medicinal Food·Ester SperoniGabbriella Innocenti
Apr 21, 2007·Phytotherapy Research : PTR·E SperoniG Innocenti
Mar 20, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Maria KakarNaseem Ullah

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