Wushenziye Formula Improves Skeletal Muscle Insulin Resistance in Type 2 Diabetes Mellitus via PTP1B-IRS1-Akt-GLUT4 Signaling Pathway

Evidence-based Complementary and Alternative Medicine : ECAM
Chunyu TianJi-An Li

Abstract

Background. Wushenziye formula (WSZYF) is an effective traditional Chinese medicine in the treatment of type 2 diabetes mellitus (T2DM). Aim. This study aimed to identify the effects and underlying mechanisms of WSZYF on improving skeletal muscle insulin resistance in T2DM. Methods. An animal model of T2DM was induced by Goto-Kakizaki diabetes prone rats fed with high fat and sugar for 4 weeks. Insulin resistance model was induced in skeletal muscle cell. Results. In vivo, WSZYF improved general conditions and decreased significantly fasting blood glucose, glycosylated serum protein, glycosylated hemoglobin, insulin concentration, and insulin resistance index of T2DM rats. In vitro, WSZYF enhanced glucose consumption in insulin resistance model of skeletal muscle cell. Furthermore, WSZYF affected the expressions of molecules in regulating T2DM, including increasing the expressions of p-IRS1, p-Akt, and GLUT4, reducing PTP1B expression. Conclusion. These findings displayed the potential of WSZYF as a new drug candidate in the treatment of T2DM and the antidiabetic mechanism of WSZYF is probably mediated through modulating the PTP1B-IRS1-Akt-GLUT4 signaling pathway.

References

Sep 15, 1993·Biochemical and Biophysical Research Communications·F KanaiY Ebina
May 4, 2011·World Journal of Diabetes·Vandana Saini
Nov 15, 2011·Diabetes Research and Clinical Practice·David R WhitingJonathan Shaw
Dec 23, 2011·Bioorganic & Medicinal Chemistry Letters·Dipam PatelPrashant Kapadnis
Nov 6, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Jeevan K PrasainJ Michael Wyss
Mar 28, 2013·European Journal of Medicinal Chemistry·Qing-Chao LiuYing-Xia Li
May 24, 2013·Journal of Pharmacological Sciences·Tomohito ShibataKumi Satoh
Dec 21, 2013·Diabetes Care·UNKNOWN American Diabetes Association
May 12, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohamad Hafizi Abu BakarHasniza Zaman Huri
Dec 23, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qingpu LiuGuoping Peng
May 2, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Lixia YangTonghua Liu
Jul 15, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Caio Y YonamineUbiratan F Machado

❮ Previous
Next ❯

Citations

Nov 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ping ZhaoXinzhou Yang
Jan 10, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Chunyu TianXiaojin La
Oct 26, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Chunyu TianLeilei Ma
May 14, 2020·Journal of Cardiovascular Pharmacology·Fangyan YanJinping Li
Jan 16, 2021·Food & Nutrition Research·Rongrong LuZhuoqin Jiang
Apr 1, 2021·Journal of Evidence-based Integrative Medicine·F D Y Kamga-SimoL J Shai
Apr 8, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Shanshan SongXue Yu
Dec 18, 2018·Pharmacology & Therapeutics·Asuncion Martinez-AntonPascal Chanez

❮ Previous
Next ❯

Methods Mentioned

BETA
Biosensors
protein assay

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

© 2022 Meta ULC. All rights reserved