Wwox Deficiency Causes Downregulation of Prosurvival ERK Signaling and Abnormal Homeostatic Responses in Mouse Skin

Frontiers in Cell and Developmental Biology
Ying-Tsen ChouLi-Jin Hsu

Abstract

Deficiency of tumor suppressor WW domain-containing oxidoreductase (WWOX) in humans and animals leads to growth retardation and premature death during postnatal developmental stages. Skin integrity is essential for organism survival due to its protection against dehydration and hypothermia. Our previous report demonstrated that human epidermal suprabasal cells express WWOX protein, and the expression is gradually increased toward the superficial differentiated cells prior to cornification. Here, we investigated whether abnormal skin development and homeostasis occur under Wwox deficiency that may correlate with early death. We determined that keratinocyte proliferation and differentiation were decreased, while apoptosis was increased in Wwox-/- mouse epidermis and primary keratinocyte cultures and WWOX-knockdown human HaCaT cells. Without WWOX, progenitor cells in hair follicle junctional zone underwent massive proliferation in early postnatal developmental stages and the stem/progenitor cell pools were depleted at postnatal day 21. These events lead to significantly decreased epidermal thickness, dehydration state, and delayed hair development in Wwox-/- mouse skin, which is associated with downregulation of prosurvival MEK/ER...Continue Reading

References

Jul 10, 2001·The Journal of Investigative Dermatology·S Müller-RöverR Paus
Apr 25, 2002·Nature Reviews. Genetics·Elaine Fuchs, Srikala Raghavan
Oct 14, 2003·Biochemical Pharmacology·Nan-Shan ChangUdo Oppermann
Mar 6, 2004·Science·W James Nelson, Roel Nusse
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Feng-Jie LaiHamm-Ming Sheu
Oct 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Muller FabbriCarlo M Croce
Jan 31, 2006·Journal of Cell Science·Laura Alonso, Elaine Fuchs
Aug 31, 2006·Journal of Molecular Histology·Maria I NunezC Marcelo Aldaz
Dec 5, 2006·Trends in Molecular Medicine·Nan-Shan ChangHamm-Ming Sheu
Jan 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dimitrios IliopoulosKay Huebner
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Rami I AqeilanCarlo M Croce
May 20, 2008·The Journal of Biological Chemistry·Rami I AqeilanCarlo M Croce
Jul 3, 2008·Cell Stem Cell·Jonathan A NowakElaine Fuchs
Feb 12, 2009·Nature Reviews. Molecular Cell Biology·Cédric Blanpain, Elaine Fuchs
Jul 18, 2009·Cell Death and Differentiation·R Yi, E Fuchs
Nov 13, 2012·Expert Review of Endocrinology & Metabolism·Daniel D BikleChia-Ling Tu
Mar 26, 2013·International Journal of Molecular Medicine·Junjie QuXiaoping Wan
Sep 11, 2013·The Journal of Cell Biology·Michaela T NiessenCarien M Niessen
Feb 15, 2014·Advances in Wound Care·Makoto Senoo
Feb 20, 2014·The Journal of Biological Chemistry·Mohammad Abu-OdehRami I Aqeilan
Jun 19, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Magdalena NowakowskaAndrzej Kazimierz Bednarek
Jul 6, 2014·Cold Spring Harbor Perspectives in Medicine·Kai Kretzschmar, Fiona M Watt
Jul 12, 2014·Cell Death and Differentiation·M Abu-Remaileh, R I Aqeilan
Aug 8, 2014·Nature Medicine·Ya-Chieh HsuElaine Fuchs
Dec 30, 2014·Experimental Biology and Medicine·Morgan S Schrock, Kay Huebner
Jan 18, 2015·Experimental Biology and Medicine·Jui-Yen LoLi-Jin Hsu
Feb 27, 2015·Journal of Human Genetics·Mylène ValdugaPhilippe Jonveaux

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Citations

May 6, 2021·Cells·Karim TaouisFrançois Lallemand
May 6, 2021·Biomolecules·Meera KrishnanPrasad Abnave

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Methods Mentioned

BETA
protein assay
Profiler
transmission electron microscopy
flow cytometry
light microscopy
confocal microscopy

Software Mentioned

BD CellQuest Pro
ImageJ
Pro Plus
GraphPad
Prism
Image
IHC Profiler

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