X-box-binding protein 1-modified neural stem cells for treatment of Parkinson's disease

Neural Regeneration Research
Lihui SiManhua Cui

Abstract

X-box-binding protein 1-transfected neural stem cells were transplanted into the right lateral ventricles of rats with rotenone-induced Parkinson's disease. The survival capacities and differentiation rates of cells expressing the dopaminergic marker tyrosine hydroxylase were higher in X-box-binding protein 1-transfected neural stem cells compared to non-transfected cells. Moreover, dopamine and 3,4-dihydroxyphenylacetic acid levels in the substantia nigra were significantly increased, α-synuclein expression was decreased, and neurological behaviors were significantly ameliorated in rats following transplantation of X-box-binding protein 1-transfected neural stem cells. These results indicate that transplantation of X-box-binding protein 1-transfected neural stem cells can promote stem cell survival and differentiation into dopaminergic neurons, increase dopamine and 3,4-dihydroxyphenylacetic acid levels, reduce α-synuclein aggregation in the substantia nigra, and improve the symptoms of Parkinson's disease in rats.

Citations

Apr 15, 2015·Frontiers in Aging Neuroscience·Gabriela MercadoClaudio Hetz
May 28, 2019·Frontiers in Neuroscience·Šárka LehtonenJari Koistinaho
Nov 7, 2016·Apoptosis : an International Journal on Programmed Cell Death·Chunchen XiangFang Han
Jan 19, 2016·Frontiers in Cell and Developmental Biology·Emma R PerriJulie D Atkin
Jan 29, 2019·Frontiers in Neuroscience·Zeba MueedNitesh Kumar Poddar

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Methods Mentioned

BETA
electrophoresis

Software Mentioned

SPSS

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