X chromosome inactivation: when dosage counts

Cell
Elphège P Nora, E Heard

Abstract

How do mammals count their X chromosomes and keep only one X active per cell? In this issue, Jonkers et al. (2009) show that Rnf12/RLIM, encoded by the X-linked gene Rnf12, induces X chromosome inactivation only when present above a certain threshold, a condition fulfilled when at least two Xs are active.

References

Sep 20, 2008·Science·Pablo NavarroPhilip Avner
Mar 17, 2009·Eukaryotic Cell·Wilfried Jonkers, Martijn Rep

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Citations

Sep 11, 2010·Briefings in Functional Genomics·Charlotte Proudhon, Déborah Bourc'his
Feb 8, 2011·PLoS Genetics·Edda G SchulzEdith Heard

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