X-linked adrenoleukodystrophy: correlation between Loes score and diffusion tensor imaging parameters

Radiologia brasileira
Sergio Eiji OnoLisandro Lima Ribeiro

Abstract

The present study was aimed at evaluating the correlation between diffusion tensor imaging parameters and Loes score as well as whether those parameters could indicate early structural alterations. Diffusion tensor imaging measurements were obtained in 30 studies of 14 patients with X-linked adrenoleukodystrophy and were correlated with Loes scores. A control group including 28 male patients was created to establish agematched diffusion tensor imaging measurements. Inter- and intraobserver statistical analyses were undertaken. Diffusion tensor imaging measurements presented strong Pearson correlation coefficients (r) of -0.86, 0.89, 0.89 and 0.84 for fractional anisotropy and mean, radial and axial diffusivities (p < 0.01). Analysis of changes in diffusion tensor measurements at early stage of the disease indicates that mean and radial diffusivities might be useful to predict the disease progression. Measurements of diffusion tensor parameters can be used as an adjunct to the Loes score, aiding in the monitoring of the disease and alerting for possible Loes score progression in the range of interest for therapeutic decisions.

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Citations

May 20, 2015·Radiologia brasileira·Ricardo SchwingelFabiano Reis
Mar 10, 2017·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Christel TranSaadet Mercimek-Mahmutoglu
Sep 29, 2020·Journal of Child Neurology·Prateek Kumar Panda, Indar Kumar Sharawat

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Adrenoleukodystrophy

Adrenoleukodystrophy (ALD), the most frequent peroxisomal disorder, is an X-linked disorder caused by a defect in the metabolism of long chain fatty acids leading to demyelination, neurodegeneration, and death. Here is the latest research.