X-linked inhibitor of apoptosis protein mediates neddylation by itself but does not function as a NEDD8-E3 ligase for caspase-7

FEBS Letters
Taiki NaganoShinji Kamada

Abstract

X-linked inhibitor of apoptosis protein (XIAP) is a potent antagonist of caspases, and functions as a ubiquitin-E3 ligase by itself and for caspases. Recently, NEDD8, a ubiquitin-like modifier, has been suggested to be used for modification of caspase-7 mediated by XIAP. However, it is not clear whether caspase-7 is a bona fide target for NEDD8. Here we showed that no neddylation of caspase-7 but that of XIAP itself was observed under the conditions in which caspase-7 was modified with ubiquitin. These results reveal that XIAP does not function as a NEDD8-E3 ligase for caspase-7 in vivo.

References

Aug 31, 1993·Biochemical and Biophysical Research Communications·S KumarM Noda
Nov 14, 1997·The Journal of Biological Chemistry·T KamitaniE T Yeh
Jun 17, 1998·Genes & Development·V Cryns, J Yuan
Aug 8, 1998·Genes & Development·F OsakaS Kato
Aug 28, 1998·Science·N A Thornberry, Y Lazebnik
Apr 17, 1999·The Journal of Biological Chemistry·L Gong, E T Yeh
Jun 29, 2000·Annual Review of Biochemistry·W C EarnshawS H Kaufmann
Jun 4, 2002·Nature Reviews. Molecular Cell Biology·Guy S Salvesen, Colin S Duckett
Jul 18, 2002·The Journal of Biological Chemistry·Marion MacFarlaneGerald M Cohen
Mar 17, 2004·Oncogene·Zhen-Qiang PanKenneth Wu
Apr 3, 2004·Molecular and Cellular Biology·Natalie H StickleMichael Ohh
Apr 14, 2004·The Journal of Biological Chemistry·Emma M CreaghSeamus J Martin
Jul 10, 2004·Cell·Dimitris P XirodimasDavid P Lane
Apr 2, 2005·Nature Reviews. Molecular Cell Biology·David L Vaux, John Silke
Nov 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·John SilkeDavid L Vaux
Jun 1, 2006·The Journal of Biological Chemistry·Shlomo OvedYosef Yarden
Sep 19, 2006·The Journal of Biological Chemistry·Ian R WatsonMeredith S Irwin
Jan 22, 2008·Molecular Cell·Thimo KurzFrank Sicheri
Aug 29, 2009·EMBO Reports·Anders SundqvistDimitris P Xirodimas
Sep 14, 2010·Molecular Cell·Daniel C ScottBrenda A Schulman
Dec 15, 2010·Molecular Cell·Meike BroemerPascal Meier
Jan 5, 2011·The Journal of Biological Chemistry·Ji-Hye RyuYang-Sook Chun
Apr 12, 2011·PloS One·Toshiaki HashimotoShinji Kamada
Oct 19, 2011·The Biochemical Journal·Roland HjerpeThimo Kurz

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Citations

Jan 15, 2014·Antioxidants & Redox Signaling·Yongchao ZhaoYi Sun
Dec 23, 2014·Nature Reviews. Molecular Cell Biology·Radoslav I EnchevMatthias Peter
Dec 3, 2014·Molecular and Cellular Biology·Jesus A SegoviaSantanu Bose
Dec 19, 2018·Chemical Biology & Drug Design·Jonathan J ChenDonald P Visco
Jul 18, 2018·Proceedings of the National Academy of Sciences of the United States of America·Adelajda ZorbaMatthew F Calabrese
Nov 17, 2020·Frontiers in Medicine·Jiping YaoMin Zheng

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