PMID: 2493577Mar 1, 1989Paper

X-ray- and mitomycin C (MMC)-induced chromosome aberrations in spermiogenic germ cells and the repair capacity of mouse eggs for the X-ray and MMC damage

Mutation Research
Y MatsudaI Tobari

Abstract

Chromosome aberrations induced at the first-cleavage metaphase of eggs fertilized with sperm recovered from spermiogenic cells which had been X-irradiated and treated with mitomycin C (MMC) at various stages were observed using in vitro fertilization and embryo culture technique. Furthermore, the repair capacity of the fertilized eggs for X-ray- and MMC-induced DNA damage which was induced in the spermiogenic cells and retained in the sperm until fertilization was investigated by analysis of the potentiation effects of 2 repair inhibitors, 3-aminobenzamide (3AB) and caffeine on the yield of chromosome aberrations. The frequency of chromosome aberrations observed in the eggs fertilized with sperm recovered from the early spermatid to late spermatocyte stage with X-irradiation of 4 Gy (16-20 days after X-irradiation) was markedly higher than that in the eggs fertilized with sperm recovered from spermatozoa to late spermatid stage (0-8 days after X-irradiation). The induced chromosome aberrations predominantly consisted of chromosome-type aberrations, the main type being chromosome fragment followed by chromosome exchange through all the spermiogenic stages. On the other hand, a high frequency of chromosome aberrations was not ind...Continue Reading

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Citations

Dec 1, 1996·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·F MarchettiA J Wyrobek
Dec 13, 2000·Mutation Research·A Russo
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·C G FragaB N Ames
Jan 26, 2008·The Quarterly Review of Biology·Klaus Reinhardt
Jun 23, 2009·Fertility and Sterility·Cristóbal AguilarNicolás Garrido
May 9, 2015·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Carole L YaukGeorge R Douglas
Dec 20, 2005·Molecular Reproduction and Development·Margot Alves Nunes DodeMarc-André Sirard
Jun 22, 2017·Drug and Chemical Toxicology·Dhamraa Waleed Al-DualimiAmin Malik Shah Abdul Majid
Jul 22, 2005·Birth Defects Research. Part C, Embryo Today : Reviews·Francesco Marchetti, Andrew J Wyrobek
Dec 23, 2004·Journal of Radiation Research·Laura TusellAnna Genescà
Sep 12, 2018·Mutagenesis·Antonella RussoFrancesca Pacchierotti
Nov 6, 2009·Mutation Research·Emad A AhmedDirk G de Rooij

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