X-ray crystal structure and EPR spectra of "arsenite-inhibited" Desulfovibriogigas aldehyde dehydrogenase: a member of the xanthine oxidase family

Journal of the American Chemical Society
D R BoerJosé J G Moura

Abstract

X-ray crystallography has been used to determine the structure of arsenite-inhibited aldehyde dehydrogenase from Desulfovibrio gigas, a member of the xanthine oxidase family of mononuclear molybdenum enzymes. The structure shows an AsO3 moiety bound to the molybdenum atom of the active site through one of the oxygen atoms. A reduced sample of arsenite-inhibited aldehyde dehydrogenase has a Mo(V) signal that shows anisotropic hyperfine and quadrupole coupling to one arsenic atom. This signal has a strong resemblance with a previously reported signal for arsenite-inhibited xanthine oxidase.

References

Oct 4, 1976·Biochemical and Biophysical Research Communications·J J MouraR Cammack
Jan 1, 1978·Bioinorganic Chemistry·J L Johnson, K V Rajagopalan
Aug 1, 1978·The Biochemical Journal·J J MouraJ Le Gall
Jan 1, 1994·Methods in Enzymology·J J Moura, B A Barata
Aug 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·R HuberM J Romão
Nov 20, 2001·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·J M RebeloM J Romão

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Citations

Mar 2, 2006·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·D Roeland BoerMaria João Romão
Dec 4, 2012·International Journal of Molecular Sciences·Kimiyoshi IchidaTakeshi Nishino
Dec 2, 2006·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Anders ThapperMaria J Romão
Sep 8, 2015·Archives of Toxicology·Marian ValkoKamil Musílek
Oct 26, 2014·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·María C GómezCarlos D Brondino
Jan 29, 2014·Chemical Reviews·Russ HillePartha Basu
Nov 22, 2016·Environmental Microbiology·Monika Tokmina-LukaszewskaGejiao Wang
Jul 12, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Jing YangMartin L Kirk
Aug 15, 2018·Proceedings of the National Academy of Sciences of the United States of America·Nathaniel R GlasserDianne K Newman
Feb 17, 2006·Current Opinion in Chemical Biology·Carlos D BrondinoJosé J G Moura
May 11, 2011·Free Radical Biology & Medicine·Swaran J S Flora

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