X-ray induced damage in DNA monitored by X-ray photoelectron spectroscopy

The Journal of Chemical Physics
Sylwia PtasińskaLeon Sanche

Abstract

In this work, the chemical changes in calf thymus DNA samples were analyzed by X-ray photoelectron spectroscopy (XPS). The DNA samples were irradiated for over 5 h and spectra were taken repeatedly every 30 min. In this approach the X-ray beam both damages and probes the samples. In most cases, XPS spectra have complex shapes due to contributions of C, N, and O atoms bonded at several different sites. We show that from a comparative analysis of the modification in XPS line shapes of the C 1s, O 1s, N 1s, and P 2p peaks, one can gain insight into a number of reaction pathways leading to radiation damage to DNA.

References

Apr 28, 2004·Radiation Research·Yan ZubavichusMichael Grunze
Mar 4, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Dmitri Y PetrovykhLloyd J Whitman
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Citations

May 9, 2012·Radiation Protection Dosimetry·Elahe Alizadeh, Léon Sanche
Nov 8, 2012·Bioinorganic Chemistry and Applications·Fangxing XiaoYi Zheng
May 19, 2016·ACS Nano·Benjamin D MyersVinayak P Dravid
May 7, 2016·PloS One·Marian MankosRonald W Davis
Jul 28, 2016·Angewandte Chemie·Thomas SchlathölterRonnie Hoekstra
Aug 28, 2014·Journal of the American Chemical Society·Sara IliafarAnand Jagota
Oct 18, 2018·Biointerphases·Hitesh PinglePeter Kingshott
Jun 4, 2019·The Journal of Chemical Physics·A D McKeeT M Orlando
Jun 20, 2014·Physical Chemistry Chemical Physics : PCCP·R A RosenbergR Naaman
Oct 16, 2012·The Journal of Physical Chemistry. a·O González-MagañaT Schlathölter
Feb 22, 2012·Biomacromolecules·María Luisa López-DonaireJulio San Román
Apr 5, 2013·The Journal of Physical Chemistry. B·Fangxing XiaoYi Zheng
Aug 1, 2013·The Journal of Physical Chemistry. B·M Nuruzzaman KhanMichael Zharnikov
Aug 21, 2020·The Journal of Physical Chemistry. B·Julia WittmarIzabella Brand
Aug 30, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Santiago HerreraRoberto C Salvarezza

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Methods Mentioned

BETA
X-ray
electrophoresis
electron

Software Mentioned

CASAXPS

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