X-ray induced photodynamic therapy (PDT) with a mitochondria-targeted liposome delivery system.

Journal of Nanobiotechnology
Xuefan GuWei Deng

Abstract

In this study, we constructed multifunctional liposomes with preferentially mitochondria-targeted feature and gold nanoparticles-assisted synergistic photodynamic therapy. We systemically investigated the in vitro X-ray triggered PDT effect of these liposomes on HCT 116 cells including the levels of singlet oxygen, mitochondrial membrane potential, cell apoptosis/necrosis and the expression of apoptosis-related proteins. The results corroborated that synchronous action of PDT and X-ray radiation enhance the generation of cytotoxic reactive oxygen species produced from the engineered liposomes, causing mitochondrial dysfunction and increasing the levels of apoptosis.

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Citations

Aug 10, 2021·Recent Patents on Anti-cancer Drug Discovery·Sepideh KhaleghiShahryar K Nikkhoi

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Methods Mentioned

BETA
X-ray
flow cytometry
Assay
fluorescence imaging
confocal microscopy
dynamic light scattering

Software Mentioned

GraphPad Prism
Fiji
ImageJ
iTEM

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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