X-ray-Mediated Release of Molecules and Engineered Proteins from Nanostructure Surfaces

ACS Applied Materials & Interfaces
Mengqi SuTing Guo

Abstract

Many applications call for initiation of chemical reactions with highly penetrating X-rays with nanometer precision and little damage to the surroundings, which is difficult to realize because of low interaction cross-sections between hard X-rays and organic matters. Here, we demonstrate that a combination of computational protein design of single conjugation site green fluorescent proteins and nanomaterial engineering of silica-covered gold nanoparticles can enhance the release efficiencies of proteins from the surface of nanoparticles. The nanoparticles, to which the proteins are attached through DNA linkers, provide increased X-ray absorption without scavenging radicals, and single conjugation sites allow efficient release of proteins.

References

Oct 29, 2004·Physics in Medicine and Biology·James F HainfeldHenry M Smilowitz
Jun 22, 2005·Chemical Communications : Chem Comm·Erika A FoleyTing Guo
Dec 22, 2005·Nature Biotechnology·Jean-Denis PédelacqGeoffrey S Waldo
Dec 29, 2010·Methods in Enzymology·Andrew Leaver-FayPhilip Bradley
Nov 17, 2011·Nature Chemical Biology·Nicholas Stephanopoulos, Matthew B Francis
Jan 21, 2012·Journal of the American Chemical Society·Neal N ChengTing Guo
Feb 21, 2013·Chemical Communications : Chem Comm·Zane B StarkewolfTing Guo
Jan 29, 2014·Contrast Media & Molecular Imaging·David P CormodeZahi A Fayad
May 15, 2018·Angewandte Chemie·Zijian ZhouXiaoyuan Chen

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Citations

Jul 17, 2019·Physical Chemistry Chemical Physics : PCCP·Ting Guo
Jul 8, 2019·Advanced Drug Delivery Reviews·Allison N DuRossConroy Sun

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