X-ray PIV measurement of blood flow in deep vessels of a rat: An in vivo feasibility study

Scientific Reports
Hanwook ParkSang Joon Lee

Abstract

X-ray PIV measurement is a noninvasive approach to measure opaque blood flows. However, it is not easy to measure real pulsatile blood flows in the blood vessels located at deep position of the body, because the surrounding tissues significantly attenuate the contrast of X-ray images. This study investigated the effect of surrounding tissues on X-ray beam attenuation by measuring the velocity fields of blood flows in deep vessels of a live rat. The decrease in image contrast was minimized by employing biocompatible CO2 microbubbles as tracer particles. The maximum measurable velocity of blood flows in the abdominal aorta of a rat model was found through comparative examination between the PIV measurement accuracy and the level of image contrast according to the input flow rate. Furthermore, the feasibility of using X-ray PIV to accurately measure in vivo blood flows was demonstrated by determining the velocity field of blood flows in the inferior vena cava of a rat. This study may serve as a reference in conducting in vivo X-ray PIV measurements of pulsatile blood flows in animal disease models and investigating hemodynamic characteristics and circulatory vascular diseases.

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Citations

Apr 19, 2017·Journal of Biomechanical Engineering·Zifeng YangBryan Ludwig
Dec 12, 2019·Royal Society Open Science·Karen LarsonAnastasios Matzavinos
Mar 1, 2018·Journal of Synchrotron Radiation·Hanwook ParkSang Joon Lee
Feb 7, 2018·Optics Express·G W GoonanS Dubsky

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Methods Mentioned

BETA
imaging
X-ray

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