PMID: 6413855Sep 1, 1983Paper

X-ray-sensitive mutant mouse cells with various sensitivities to chemical mutagens

Mutation Research
K SatoH Hama-Inaba

Abstract

Three X-ray-sensitive mutants (LX821, LX827 and LX830) have been isolated from mouse-lymphoma L5178Y cells. These mutants are much more sensitive to the lethal effects of ionizing radiation than the parental L5178Y cells but are as resistant to ultraviolet radiation as L5178Y cells. We have previously isolated a mutant M10 that is sensitive to methyl methanesulfonate (MMS) and cross sensitive to ionizing radiation and 4-nitroquinoline 1-oxide (4NQO). Unlike M10 cells, newly isolated mutants were not sensitive to MMS and were less sensitive to 4NQO. These results indicate that new mutants may be deficient in the repair of DNA damage specific to ionizing radiation. LX821 and LX827 cells were concomitantly resistant to 5-bromodeoxyuridine, whereas LX830 cells were not.

Citations

Nov 1, 1988·Mutation Research·M Z ZdzienickaJ W Simons
May 28, 2003·DNA Repair·John Thacker, Małgorzata Z Zdzienicka
Sep 1, 1988·International Journal of Radiation Biology·J S Rubin
Jan 1, 1989·Environmental and Molecular Mutagenesis·L H Thompson
Jan 1, 1991·International Journal of Radiation Biology·K Eguchi-KasaiI Kaneko

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