PMID: 2105462Jan 1, 1990Paper

X-ray sensitivity and single-strand DNA break repair in mutagen-sensitive mutants of Drosophila melanogaster

Mutation Research
D R OliveriJ B Boyd

Abstract

Mutants of Drosophila melanogaster that are sensitive to chemical mutagens were analyzed for sensitivity to X-rays and for the capacity to repair single-strand DNA breaks induced by X-rays. Analysis of X-ray sensitivity demonstrated that 74% of the mutants assayed display some X-ray sensitivity, with 75% of the sensitive lines being extremely sensitive. Repair of single-strand breaks was assayed after both high and low doses of irradiation in order to permit detection of repair over a wide range of damage. The results of this investigation fail to show a correlation between X-ray sensitivity and this particular repair process. Repair of single-strand breaks is therefore mediated by repair processes unrelated to those that are disrupted in the current mutant collection.

References

Oct 19, 1976·Biochemistry·K W KohnC A Friedman
Nov 1, 1979·Mutation Research·T D NguyenM M Green
Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·B S BakerP D Smith
Jan 1, 1989·Molecular & General Genetics : MGG·J M MasonA H Yamamoto
Jan 1, 1987·Journal of Cell Science. Supplement·J B BoydK Sakaguchi
Nov 28, 1971·Journal of Molecular Biology·W Boram, J Abelson
May 1, 1980·Somatic Cell Genetics·L H ThompsonK Brookman

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