X-ray visible and uniform alginate microspheres loaded with in situ synthesized BaSO4 nanoparticles for in vivo transcatheter arterial embolization

Biomacromolecules
Qin WangAmy Q Shen

Abstract

The lack of noninvasive tracking and mapping the fate of embolic agents has restricted the development and further applications of the transcatheter arterial embolization (TAE) therapy. In this work, inherent radiopaque embolic material, barium alginate (ALG) microspheres loaded with in situ synthesized BaSO4 (denoted as BaSO4/ALG microspheres), have been synthesized by a one-step droplet microfluidic technique. One of the advantages of our microfluidic approach is that radiopaque BaSO4 is in the form of nanoparticles and well dispersed inside ALG microspheres, thereby greatly enhancing the imaging quality. The crystal structure of in situ synthesized BaSO4 nanoparticles in ALG microspheres is confirmed by X-ray diffraction analysis. Results of in vitro and in vivo assays from digital subtraction angiography and computed tomography scans demonstrate that BaSO4/ALG microspheres possess excellent visibility under X-ray. Histopathological analysis verifies that the embolic efficacy of BaSO4/ALG microspheres is similar to that of commercially available alginate microsphere embolic agents. Furthermore, the visibility of radiopaque BaSO4/ALG microspheres under X-ray promises the direct detection of the embolic efficiency and position...Continue Reading

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Citations

Mar 1, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Azadeh PoursaidHamidreza Ghandehari
Jun 7, 2019·Advanced Materials·Jingjie HuRahmi Oklu
Nov 17, 2016·Physical Chemistry Chemical Physics : PCCP·Sergey V GermanDmitry A Gorin
Jun 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qing DuXiangliang Yang
Aug 25, 2020·Advances in Pharmacological and Pharmaceutical Sciences·Dewi Melani Hariyadi, Nazrul Islam
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Apr 14, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Yang HeJun Cao
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Aug 23, 2019·Accounts of Chemical Research·Zifu LiGuangjun Nie
Aug 19, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Guorong JiaKai Chen

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