XAF1 as a prognostic biomarker and therapeutic target in pancreatic cancer

Cancer Science
Jia HuangYao-zong Yuan

Abstract

XAF1 (X chromosome-linked inhibitor of apoptosis [XIAP]-associated factor 1) is a novel XIAP modulator that negatively regulates the anti-apoptotic effects of XIAP and sensitizes cells to other cell death triggers. It has been reported to be downregulated in a variety of human cancer cell lines. However, the role of XAF1 in pancreatic carcinogenesis remains unclear. In the present study, we investigated the prognostic values of XAF1 expression and its regulation in cancer cell growth and apoptosis both in vitro and in vivo. From the immunohistochemistry staining of tissue microarray, 40 of 89 (44.9%) pancreatic specimens showed low levels of XAF1 expression. Statistical analysis suggested the downregulation of XAF1 was significantly correlated with tumor staging (P = 0.047) and those patients with low XAF1 levels had shorter survival times (P = 0.0162). Multivariate analysis indicated that XAF1 expression was an independent prognostic indicator of the survival of patients with pancreatic cancer (P = 0.007). Furthermore, we found that restoration of XAF1 expression mediated by Ad5/F35 virus suppressed cell proliferation and induced cell cycle arrest and apoptosis, accompanied by the activation of caspases 3, 8, and 9 and poly(AD...Continue Reading

References

Apr 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M L RothenbergD D Von Hoff
Jun 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H A BurrisD D Von Hoff
Jul 17, 1997·Nature·Q L DeverauxJ C Reed
May 2, 1998·The EMBO Journal·C ScaffidiM E Peter
Feb 17, 1999·Genes & Development·Q L Deveraux, J C Reed
Feb 15, 2001·Nature Cell Biology·P ListonR G Korneluk
May 22, 2001·The Journal of Biological Chemistry·Y SuzukiR Takahashi
May 11, 2002·Nature Reviews. Cancer·Frederik H Igney, Peter H Krammer
Jun 4, 2002·Nature Reviews. Molecular Cell Biology·Guy S Salvesen, Colin S Duckett
Jan 2, 2003·Nature Reviews. Cancer·Dario C Altieri
Feb 1, 2003·Cancer Cell·John C Reed
Mar 31, 2004·Lancet·Donghui LiJames L Abbruzzese
Nov 20, 2004·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Anna S Gukovskaya, Stephen J Pandol
Dec 22, 2004·The Journal of Investigative Dermatology·Kin Cheung P NgGang Li
May 12, 2005·Gastroenterology·Günter SchneiderRoland M Schmid
Jun 22, 2005·Pancreas·Xiaozhong Guo, Zhongmin Cui
Oct 22, 2005·Nature Reviews. Cancer·Stephen W Fesik
Dec 15, 2005·International Journal of Cancer. Journal International Du Cancer·Xiaolei FangDawei Xu
Jan 25, 2006·Molecular and Cellular Biochemistry·Yan XiaAndrew C Phillips
May 5, 2006·Nature Clinical Practice. Gastroenterology & Hepatology·Matthias Löhr
May 17, 2006·Genes & Development·Aram F HezelRonald A Depinho
Jun 28, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Frederic J ReuErnest C Borden
Jul 7, 2007·The Journal of Biological Chemistry·Vinay AroraRobert G Korneluk
Sep 23, 2008·Annals of Surgical Oncology·Tomotaka ShibataKatsunobu Kawahara
Apr 10, 2009·International Journal of Cancer. Journal International Du Cancer·Shui Ping TuBenjamin Chun-Yu Wong

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Citations

Jan 30, 2013·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Ying Lin, Wei Li
Sep 7, 2013·Cell Death & Disease·T K Oberoi-KhanujaK Rajalingam
Aug 1, 2012·Gene·Manisha R SajnaniChaitanya G Joshi
Jan 1, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Stefanie KewitzMartin S Staege
Oct 8, 2015·Scientific Reports·Georgina Victoria-AcostaJorge Melendez-Zajgla
Sep 14, 2014·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Keiichi HatakeyamaTohru Mochizuki
Jan 1, 2010·Cancers·Richard Jäger, Ralf M Zwacka
Jan 1, 2011·Cancers·Simone Fulda
Oct 27, 2017·Apoptosis : an International Journal on Programmed Cell Death·Mervat S MohamedAyat G Ali
Nov 20, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ga Bin ParkDae Young Hur
Aug 30, 2014·World Journal of Gastroenterology : WJG·Xiang-Yi He, Yao-Zong Yuan
Jun 26, 2020·Pharmacology & Therapeutics·Swati KumarRichard C Turkington

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