XANAP: A real-world, prospective, observational study of patients treated with rivaroxaban for stroke prevention in atrial fibrillation in Asia

Journal of Arrhythmia
Young-Hoon KimXANAP investigators

Abstract

ROCKET AF and its East Asian subanalysis demonstrated that rivaroxaban was non-inferior to warfarin for stroke/systemic embolism (SE) prevention in patients with non-valvular atrial fibrillation (NVAF), with a favorable benefit-risk profile. XANAP investigated the safety and effectiveness of rivaroxaban in routine care in Asia-Pacific. XANAP was a prospective, real-world, observational study in patients with NVAF newly starting rivaroxaban. Patients were followed at ~3-month intervals for 1 year, or for ≥30 days after permanent discontinuation. Primary outcomes were major bleeding events, adverse events (AEs), serious AEs and all-cause mortality; secondary outcomes included stroke/SE. Major outcomes were adjudicated centrally. XANAP enrolled 2273 patients from 10 countries: mean age was 70.5 years and 58.1% were male. 49.8% of patients received rivaroxaban 20 mg once daily (od), 43.8% 15 mg od and 5.9% 10 mg od. Mean treatment duration was 296 days, and 72.8% of patients had received prior anticoagulation therapy. Co-morbidities included heart failure (20.1%), hypertension (73.6%), diabetes mellitus (26.6%), prior stroke/non-central nervous system SE/transient ischemic attack (32.8%) and myocardial infarction (3.8%). Mean CHADS...Continue Reading

References

Dec 5, 2003·Revista Panamericana De Salud Pública = Pan American Journal of Public Health
Apr 25, 2009·Stroke; a Journal of Cerebral Circulation·Ashan GunarathneGregory Y H Lip
Sep 1, 2009·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN RE-LY Steering Committee and Investigators
Jul 7, 2011·Circulation·Anthony S Kim, S Claiborne Johnston
Aug 13, 2011·The New England Journal of Medicine·Manesh R PatelUNKNOWN ROCKET AF Investigators
Aug 30, 2011·The New England Journal of Medicine·Christopher B GrangerUNKNOWN ARISTOTLE Committees and Investigators
Jun 6, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Masatsugu HoriUNKNOWN J-ROCKET AF study investigators
Mar 13, 2014·Nature Reviews. Cardiology·Ian SabirA John Camm
Apr 26, 2014·Stroke; a Journal of Cerebral Circulation·Ka Sing Lawrence WongUNKNOWN Executive Steering Committee and the ROCKET AF Study Investigators
Nov 21, 2015·Frontiers of Neurology and Neuroscience·Michael T C PoonRustam Al-Shahi Salman
Nov 28, 2015·Journal of the American College of Cardiology·Matthew W SherwoodManesh R Patel
Feb 5, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Chern-En ChiangShing-Jong Lin
Sep 24, 2016·Journal of the American College of Cardiology·Yi-Hsin ChanLai-Chu See

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Citations

Mar 28, 2019·Stroke; a Journal of Cerebral Circulation·So-Ryoung LeeGregory Y H Lip
Sep 3, 2020·The Korean Journal of Internal Medicine·Jaemin ShimYoung-Hoon Kim
Jul 9, 2021·The Korean Journal of Internal Medicine·Yae Min Park
Nov 18, 2021·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Sung Soo KimJeong Gwan Cho

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Software Mentioned

XANAP
ROCKET
XANTUS

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