Xanthan gum to tailor drug release of sustained-release ethylcellulose mini-matrices prepared via hot-melt extrusion: in vitro and in vivo evaluation

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
E VerhoevenJean-Paul Remon

Abstract

Mini-matrices (multiple-unit dosage form) with release-sustaining properties were developed by means of hot-melt extrusion using ibuprofen as the model drug and ethylcellulose as sustained-release agent. Xanthan gum, a hydrophilic polymer, was added to the formulation to increase the drug release since ibuprofen release from the ibuprofen/ethylcellulose matrices (60/40, w/w) was too slow (20% in 24 h). Changing the xanthan gum concentration as well as its particle size modified the in vitro drug release. Increasing xanthan gum concentrations yielded a faster drug release due to a higher liquid uptake, swelling and erosion rate. Regarding the effect of the xanthan gum particle size, no difference was observed for formulations containing 10% and 20% xanthan gum. However, using 30% xanthan gum, drug release was influenced by the particle size of the hydrophilic polymer due to the susceptibility of the coarser xanthan gum particles to erosion. Drug release from the mini-matrices was mainly diffusion controlled, but swelling played an important role to obtain complete drug release within 24 h. Drug release was influenced by the ionic strength of the medium as the conformation of xanthan gum molecules is determined by the salt concen...Continue Reading

References

Oct 4, 1974·European Journal of Clinical Pharmacology·J MeierR Schmidt
Jul 13, 2002·Journal of Pharmaceutical Sciences·C De BrabanderJ P Remon
Aug 23, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Jörg Breitenbach
Apr 25, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·C De BrabanderJ P Remon
May 8, 2004·International Journal of Pharmaceutics·Caroline De BrabanderJean-Paul Remon

❮ Previous
Next ❯

Citations

Apr 27, 2013·International Journal of Pharmaceutics·Justin M KeenRobert O Williams
Dec 8, 2011·Expert Opinion on Drug Delivery·Michael A RepkaNoorullah Naqvi Mohammed
Mar 16, 2011·Drug Development and Industrial Pharmacy·Sabahuddin SiddiqueJasmina Khanam
Jan 19, 2016·International Journal of Biological Macromolecules·Thawatchai PhaechamudWiwat Pichayakorn
May 20, 2011·Colloids and Surfaces. B, Biointerfaces·Andreas GryczkeDennis Douroumis
Apr 19, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cristina MaderueloJosé M Lanao
Jun 6, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Thomas QuintenChris Vervaet
May 16, 2008·International Journal of Pharmaceutics·M Gómez-BurgazS Torrado-Santiago
Nov 27, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·E VerhoevenC Vervaet
Jan 1, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Gavin P AndrewsJames W McGinity
Sep 6, 2012·International Journal of Biological Macromolecules·Munish AhujaKuldeep Singh
Dec 30, 2014·International Journal of Pharmaceutics·J ThiryB Evrard
Nov 10, 2009·International Journal of Pharmaceutics·Changyan LiWeiping Wu
Jun 25, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·E VerhoevenC Vervaet
Nov 28, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Piroska Szabó-RévészEdina Pallagi
May 31, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Thomas QuintenJean Paul Remon
Dec 30, 2014·International Journal of Pharmaceutics·Abraham G SarrafEric Doelker
Nov 12, 2017·Drug Delivery and Translational Research·Yongcheng LiChuanbin Wu
Dec 2, 2008·Expert Opinion on Drug Delivery·Michael A RepkaSampada B Upadhye
Jan 1, 2015·International Scholarly Research Notices·Helen ChattopadhyaySriparna Datta
Mar 24, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Zahari VinarovPatrick Augustijns
Jun 19, 2021·AAPS PharmSciTech·Marta F SimõesSérgio Simões
Jun 6, 2018·Biomacromolecules·Hale Cigdem ArcaKevin J Edgar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society
C De BrabanderJean-Paul Remon
European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
E VerhoevenChris Vervaet
International Journal of Pharmaceutics
C De BrabanderJean-Paul Remon
European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
L Diane BruceJames W McGinity
European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
E VerhoevenChris Vervaet
© 2021 Meta ULC. All rights reserved