Jan 1, 1988

Xanthine oxidase activity and immunologically detectable protein in the C57B1/6 mouse

The International Journal of Biochemistry
K M Manchester, N K Amy


1. Xanthine oxidase (XO) was purified from livers of C57B1/6 mice. Antibodies generated against the purified protein were used in an immunoassay to measure total XO protein. 2. Both the specific activity and amount of XO protein were greater in the proximal small intestine than in the liver. A pool of inactive enzyme was present in the small intestine which developed after weaning. 3. Male C57B1/6 mice had the same XO specific activity as females and neither the hepatic nor the intestinal XO activity were affected by the level of dietary protein. 4. When mice were fed diets with tungsten, XO activity was lost and the amount of XO protein in the small intestine was decreased.

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Mentioned in this Paper

Small Intestinal Wall Tissue
Xanthine Oxidase
Entire Small Intestine
Neoplasm of Uncertain or Unknown Behavior of Small Intestine
Immunoassay Method
Dietary Proteins
XDH gene

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