Xanthine oxidase activity in the dexamethasone-induced hypertensive rat

Microvascular Research
Camille J WallworkGeert W Schmid-Schönbein

Abstract

Hypertension may be associated with an increase in oxidative stress as a possible mechanism for the increased vascular tone and organ injury. Previously, we reported an increased production of reactive oxygen species and endothelial cell death in the microcirculation of hypertensive rats. We hypothesize that xanthine oxidase (XO) may be a potential source of oxidants induced by glucocorticoid-induced hypertension. Male Wistar rats were administered dexamethasone (0.5 mg/kg/day) for 5 days to induce hypertension. After general anesthesia, cremaster muscle was collected for analysis of XO and xanthine dehydrogenase (XDH) activities. The mean blood pressure and XO levels in cremaster muscle were significantly increased in the dexamethasone-treated rats compared with controls. There was a strong age-dependent rise in total XO + XDH activity in all groups. To inhibit XO, we administered allopurinol (ALLO, 0.4 mg/mL) in the drinking water to a subset of control and dexamethasone-treated rats during a 5-day treatment. The ALLO significantly reduced the mean arterial blood pressure in the dexamethasone-treated rats. Although in the cremaster muscle the total XO + XDH levels were not completely reduced with ALLO, the XO levels of the de...Continue Reading

References

Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·K NakazonoM Inoue
Feb 1, 1991·Hypertension·H TrachtmanS Futterweit
Mar 1, 1991·Hypertension·G W Schmid-SchönbeinB W Zweifach
Jan 17, 1985·The New England Journal of Medicine·J M McCord
Oct 1, 1987·Circulation Research·B Schoutsen, J W de Jong
Jul 1, 1995·Clinical and Experimental Hypertension : CHE·G W VegaI J de la Riva
Jan 1, 1993·Free Radical Research Communications·K V Kumar, U N Das
Apr 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·C J KenyonR Fraser
Nov 1, 1995·International Journal of Microcirculation, Clinical and Experimental·H SuzukiG W Schmid-Schönbein
Mar 1, 1996·Hypertension Research : Official Journal of the Japanese Society of Hypertension·T Saruta
Jan 1, 1996·Free Radical Biology & Medicine·A S KleinG B Bulkley
Nov 1, 1996·Clinical and Experimental Hypertension : CHE·M A NewazN N Htut
Dec 24, 1997·Hypertension·A SweiG W Schmid-Schönbein
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·H SuzukiG W Schmid-Schönbein
Apr 30, 1998·Molecular and Cellular Biochemistry·S Rajashree, R Puvanakrishnan
Nov 4, 1998·Free Radical Biology & Medicine·F LacyG W Schmid-Schönbein
Oct 16, 1999·Hypertension·M McIntyreA F Dominiczak
Oct 21, 2000·American Journal of Hypertension·C Qiu, C Baylis
Dec 19, 2000·Biochemical and Biophysical Research Communications·S L Planey, G Litwack
Jan 3, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A S Brem
Jun 16, 2001·Journal of Vascular Research·H H LimG W Schmid-Schönbein

❮ Previous
Next ❯

Citations

Mar 7, 2008·Antioxidants & Redox Signaling·Moo Yeol Lee, Kathy K Griendling
Jul 12, 2007·Pharmacogenetics and Genomics·Felipe J ChavesJosep Redon
Oct 18, 2006·Clinical and Experimental Pharmacology & Physiology·Charles K MondoTi-Gang Huang
Apr 19, 2007·Clinical and Experimental Pharmacology & Physiology·Sharon L H OngJudith A Whitworth
Aug 21, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jin YangYuhei Kawano
Apr 25, 2008·Journal of the American Society of Nephrology : JASN·Julie E GoodwinDavid S Geller
May 10, 2008·Cardiovascular Therapeutics·Jacob George, Allan D Struthers
Mar 13, 2014·TheScientificWorldJournal·Urszula Gawlik-DzikiIwona Kowalska
Feb 26, 2015·Antioxidants & Redox Signaling·Rayomand S KhambataAmrita Ahluwalia
Jun 3, 2014·Biochimica Et Biophysica Acta·Maria Giulia BattelliLetizia Polito
Jul 14, 2016·The Journal of Pharmacology and Experimental Therapeutics·Alexandra E Soto-PiñaRandy Strong
Dec 14, 2007·Free Radical Research·E CrimiC Napoli
Aug 9, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tsai-Der ChuangVirender K Rehan
Jan 15, 2005·American Journal of Physiology. Heart and Circulatory Physiology·F A DeLanoG W Schmid-Schönbein
Mar 18, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Adel BoueizPaul M Hassoun
Mar 9, 2007·American Journal of Physiology. Renal Physiology·Ruisheng LiuOscar A Carretero
Sep 15, 2019·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Gentao LiYoucai Zhang
Mar 17, 2011·Blood Pressure·Katarzyna Kostka-JeziornyAndrzej Tykarski
Sep 23, 2006·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Frank A DeLanoGeert W Schmid-Schönbein
May 19, 2021·Journal of Cardiovascular Pharmacology·Wojciech GilewskiGrzegorz Grześk

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.